Broad Institute Uses AI to Design New Antibiotics and Predict Drug Toxicity

• University of South Florida engineering Professor David Simmons led a research team that solved a century-old materials science puzzle: how tiny carbon black particles transform soft rubber into material strong enough to support loaded aircraft. • The findings, published this week in the Proceedings of the National Academy of Sciences, show that refining existing models to reflect carbon black's real structure and dispersion patterns provided the answer. • The discovery matters for the $260 billion global tire industry and could lead to designing safer, longer-lasting materials used in car tires, aircraft components, industrial seals, and medical devices.

• McGovern Medical School at UTHealth Houston launched the Center for Innovation in Congenital Heart Disease, a multidisciplinary center bringing together experts in medicine, science, and engineering to transform understanding and treatment of the condition. • A major research focus involves recreating early human heart development using stem cells and bioprinted structures to study how congenital defects form. • The center bridges discovery and clinical care by advancing research, developing technologies, and translating innovations into patient treatment solutions across a lifetime of care.

• Researchers published the most thorough study of cosmic expansion in the journal Astronomy & Astrophysics on April 10, combining decades of research to derive the most precise Hubble constant yet while confirming that tension between early and late-universe measurements persists. • The study, launched at an International Space Science Institute Breakthrough Workshop in Bern, Switzerland in March 2025, expanded the cosmic distance ladder into a comprehensive survey called the Local Distance Network, achieving a goal considered 'potentially unreachable' a decade ago. • Study co-author Richard Anderson from the University of Göttingen stated that the Hubble tension reveals that 'something's missing' in the current understanding of basic physics on cosmological scales.

• Scientists at the Indian Institute of Science, working with collaborators from Japan's National Institute for Materials Science, have observed electrons in graphene flowing like a nearly frictionless liquid, defying a core law of physics. • Researchers created exceptionally clean graphene samples and measured electrical and thermal conductivity, finding that as electrical conductivity rose, thermal conductivity dropped—the opposite of expected behavior. • The team discovered the fluid's viscosity is extremely low, making it one of the closest realizations of a perfect fluid ever observed, establishing graphene as an accessible platform for studying extreme physics phenomena.

• Researchers at the Facility for Rare Isotope Beams (FRIB) directly measured the proton capture reaction of arsenic-73 forming selenium-74, the lightest p-nucleus, using a rare isotope beam. • Led by Artemis Tsantiri, the study involved over 45 scientists from 20 U.S., Canadian, and European institutions, published in Physical Review Letters. • This first-of-its-kind experiment sharpens models of p-nuclei formation, proton-rich heavy isotopes that have puzzled astronomers.

• Brookhaven National Laboratory researchers created superconducting quantum interference devices (SQUIDs) using transition metal silicides, compatible with silicon manufacturing processes. • The technique adapts standard electronics methods, marking a milestone for scalable quantum systems on April 14, 2026. • This bridges gaps in quantum computing hardware by enabling integration with existing semiconductor fabs.

• U.S. Energy Secretary visited the DIII-D National Fusion Facility at General Atomics, the largest magnetic fusion research site in the United States, on April 14, 2026. • During the tour, Secretary Wright, along with executives Gil and Prochaska, engaged with DOE-funded scientists and engineers advancing fusion power plant technologies. • The visit highlights fusion as a promising energy breakthrough, with the secretary calling it 'what powers the stars and why I went to MIT.'

• Texas A&M researchers developed a nasal spray therapy that reverses brain aging by healing inflammation and restoring memory function. • The treatment targets age-related cognitive decline, turning 'brain fog to brain focus' in preclinical models. • Announced on April 14, 2026, it reshapes future therapies for neurodegenerative diseases.

• Preliminary data from the Simonyi Survey Telescope at NSF-DOE Vera C. Rubin Observatory revealed over 11,000 new asteroids, including hundreds beyond Neptune and 33 near-Earth objects. • University of Washington scientists contributed to the ultrafast alerting system detecting up to seven million cosmic changes nightly. • Findings enhance solar system mapping and planetary defense efforts.

• Scientists at INRS have identified a family of enzymes known as Ssn that can make targeted cuts in single-stranded DNA, a capability never before achieved. • This discovery fills a major gap in biotechnology by providing new tools for DNA manipulation and genetic engineering applications. • The breakthrough has significant implications for advancing biotechnology research and developing new therapeutic approaches.

• Researchers have developed a compact CRISPR system capable of achieving up to 90% efficiency in targeted in-body gene editing applications. • The breakthrough addresses previous limitations of CRISPR technology, enabling more precise genetic modifications for therapeutic purposes. • This advancement could significantly improve treatment options for genetic disorders and certain cancers by allowing safer, more effective gene therapy interventions.