Collapse of US-Iran talks heightens fears of prolonged energy shock

Mo-Rez reduced or eliminated tumours in over 60% of patients and is expected to be a blockbuster drugGSK has revealed positive results for a treatment for gynaecological cancers as its chief executive, Luke Miels, steps up drug development efforts at the group.The company said that in an early-stage trial Mocertatug Rezetecan, known as Mo-Rez, shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer. Continue reading...

Report says company did not pay tens of thousands in tax on dividends given to Reform UK deputy leader and trustRichard Tice’s company has been accused of breaking the law by allegedly failing to pay tens of thousands of pounds in tax on dividends that were paid to him and his offshore trust.Reform UK’s multimillionaire deputy leader is alleged to have received at least £91,000 in excess payments as a result, the Sunday Times reported. Dan Neidle of Tax Policy Associates – whose analysis was cited by the newspaper – said that further analysis suggested that the total in tax that should have been paid by Tice’s company was about £120,000. Continue reading...

Prime minister has been trailing in the polls to Péter Magyar in race that could have repercussions for Europe, the US and RussiaHello from Budapest where Hungarians are voting in a closely contested election that could oust Viktor Orbán after 16 years in power and potentially reshape the central European country’s relations with the EU, Moscow and Washington.Pre-election day polls appeared to suggest that Péter Magyar of the centre-right Tisza party could be on course to win the election, ending Orbán’s era, much criticised for weakening the rule of law and civil liberties, and raising hopes of a more pro-European government in Budapest. Continue reading...

John Brennan says president who made volatile remarks about destroying Iranian civilization ‘is clearly unhinged’The former Central Intelligence Agency director John Brennan has added his name to growing calls for the president to be ousted on grounds that he is unfit for the job, arguing that the US constitution’s 25th amendment addressing involuntary removal from office was “written with Donald Trump in mind”.Brennan, who served as head of the spy agency during Barack Obama’s presidency, told MS Now on Saturday that Trump’s recent volatile remarks about destroying Iranian civilization and the danger he posed to so many lives merited his removal from the Oval Office. Continue reading...

PM tells Guardian Australia Hezbollah should cease reprisals and confirms Australia’s military surveillance aircraft will remain in regionGet our breaking news email, free app or daily news podcastAustralia’s prime minister, Anthony Albanese, has urged Israel to stop its attacks on Lebanon and raised concern over its intensified military campaign on Beirut and the country’s south after the ceasefire in the Middle East.Albanese also called on Hezbollah to cease attacks on Israel, reiterating his government’s belief that the Middle East ceasefire must include Lebanon. The prime minister also confirmed Australia’s military surveillance aircraft would remain in the region for at least another month beyond its initial deployment. Continue reading...

Experts say our preoccupation with net overseas migration figures has distracted from a more meaningful discussion on the ‘scale of temporariness’Get our breaking news email, free app or daily news podcastAustralia should set immigration targets to achieve a “stable temporary population” to address the ballooning number of nonpermanent residents that has stretched the country’s public services and housing, a new report argues.Temporary migrants as a share of the total population has more than doubled over the past 15 years, from 2.7% in 2010, to more than 6%. Continue reading...

Two sides tested one another’s resolve but timeframe meant it was probably unrealistic to expect deal Middle East crisis – live updatesIt was if the two delegations in the Iran-US peace talks in Islamabad hoped that the sheer number of negotiators flown into Pakistan could overcome the handicap of having only a finite number of hours in which to settle a 20-year dispute over Iran’s nuclear ambitions, now overlaid by complex new issues such as future control of the strait of Hormuz and US compensation for its attack on Iran.Iran sent two planeloads of negotiators, including many members of the Islamic Revolutionary Guard Corps (IRGC) present to ensure that no gains made in the field were relinquished at the diplomatic table. Diplomats fanned out across political, legal, security, economic and military files. One Iranian-drafted technical explanation on nuclear facility safety ran to more than 100 pages. Continue reading...

Shooting under investigation but no details yet released about a suspect, a possible motive or any arrestsAt least six people were shot, including one fatally, at a fast-food chain restaurant in Union Township, New Jersey, on Saturday night, according to preliminary reports.The Gun Violence Archive, a nonpartisan reference resource, listed the reported shooting at the Chick-fil-A restaurant in the 2300 block of Route 22 as the 100th mass shooting documented in the US this year, as of Sunday. The archive defines mass shootings as cases in which four or more victims are wounded or killed. Continue reading...

Hundreds of officers deployed to regain control of O’Connell Street on sixth day of protests by farmers and hauliersPolice have cleared a blockade of central Dublin by farmers and hauliers who were protesting over fuel prices, signalling a possible end to six days of protests that have roiled Ireland.Mounted units and hundreds of officers regained control of O’Connell Street in a peaceful operation that emptied the thoroughfare of trucks and tractors on Sunday morning. Continue reading...

Oliuwadamilola Ogunyankinnu will appear in court on Monday over fatal stabbing in Primrose HillA man has been charged with murder after a 21-year-old was fatally stabbed in north London, police said.Finbar Sullivan died on Tuesday April 7 after the alleged attack in Primrose Hill. On Sunday, Oliuwadamilola Ogunyankinnu, 27, was charged with murder. Continue reading...

President has long been a fan of mixed martial artsIvanka and Donald Trump Jr also at eventDonald Trump and US secretary of state Marco Rubio attended a UFC event in Miami night on Saturday as peace talks with Iran failed on the other side of the world.Trump entered the Kaseya Center shortly after 9pm alongside several members of his family and UFC chief Dana White, who has been a supporter of the president since his first term. Seated nearby was Rubio as well as US ambassador to India Sergio Gor, the rapper Vanilla Ice and former FBI deputy director Dan Bongino. Continue reading...