Congo Ebola response strained a month after WHO declares international emergency

• The 2025 gastroenterology year in review highlights significant medical progress, including new FDA approvals and breakthroughs in treating Inflammatory Bowel Disease (IBD). • A key development is the introduction of IL-23 therapies and updated American Gastroenterological Association (AGA) guidelines that advocate for the early use of advanced therapies in Crohn's disease.

• Declining vaccination rates have led to a resurgence of measles, prompting biotech companies and researchers to seek pharmaceutical treatments for the disease. • Dr. Plemper of Georgia State University is working on a drug that could potentially be used off-label to treat measles patients if approved.

• Millions of Americans remain interested in GLP-1 medications for weight loss and health management but have not yet begun treatment. • According to Ondra Health, the primary obstacle for these potential patients has shifted from a lack of awareness or access to a lack of trust in the medications.

• The head of Africa's Centres for Disease Control and Prevention warned on Tuesday, June 16, that the current Ebola outbreak in Congo could become the worst on record. • A critical failure in containment has occurred, with tens of thousands of individuals who were in contact with infected patients remaining untraced.

• New data highlight how structural racism, policy, and pricing continue to drive racial and ethnic disparities in U.S. healthcare access and outcomes. • Sickle cell disease (SCD), which primarily affects non-Hispanic Black or African American individuals, remains a critical focus as it can shorten life expectancy by approximately 20 years.

• A new study has revealed the neurological process by which the brain updates predictions and adapts to change, specifically regarding how it distinguishes between internal and external sounds. • Separate research has identified a gut-based mechanism that links sleep apnea to an increased risk of heart disease.

• The Middle East and North Africa (MENA) region is experiencing a growth in clinical trials research, specifically focusing on genetic disorders. • The Catalogue for Transmission Genetics in Arabs (CTGA) is being utilized to track and list genetic conditions prevalent across the Arab world.

• The U.S. federal government has implemented funding cuts and personnel downsizing within biopreparedness programs dedicated to high-consequence infectious diseases (HCID). • These reductions occur while the U.S. is actively managing threats from Ebola and a Hantavirus cluster associated with cruise ship travel.

• Experts are calling for public investment to develop a vaccine for the Bundibugyo ebolavirus, noting that previous Zaire ebolavirus vaccines required billions of dollars and decades of research. • The proposed strategy involves initial laboratory testing, small-scale clinical trials to ensure safety and antibody response, and the pre-emptive manufacturing of doses.

• Scientists are launching clinical trials for several drugs that showed promise in preliminary studies to combat a widening Ebola outbreak. • The trials are focusing on treatments for the virus currently affecting regions such as the Democratic Republic of Congo, including the town of Mongbwalu.

• The FDA has issued multiregional guidance to optimize global hematology trials, emphasizing the need for better communication between regulators, trial designers, and investigators. • Key requirements include maintaining balanced regional enrollment and implementing rigorous control arms that remain relevant to the U.S. healthcare landscape.