New Coalition Tackles Science Reproducibility Crisis in Alzheimer's Research

• A new study finds that exposure to PFAS (per- and polyfluoroalkyl substances)—chemicals used in non-stick coatings and water-resistant products—is linked to low bone density in teenagers. • The research, announced by the Endocrine Society, involved collaboration between the CDC, University of Cincinnati College of Medicine, University of Pennsylvania, Simon Fraser University, and George Washington University. • The finding adds to growing evidence that PFAS contamination poses significant health risks, particularly during critical periods of skeletal development in adolescence.

• The U.S. Department of Energy announced $293 million in funding to advance the Genesis Mission's efforts to tackle the nation's most complex science and technology challenges. • The funding represents a significant federal commitment to supporting breakthrough scientific research and innovation across multiple fields.

• The United States saw a record amount of new clean power capacity come online in 2025, according to a report released today by the Environmental Defense Fund. • Despite the record deployment, the renewable energy sector faced significant headwinds including project delays and cancellations that threatened to slow progress. • The achievement underscores continued momentum in U.S. transition toward clean electricity despite policy uncertainties and regulatory challenges.

• A new study published in the journal Science documents that climate change is making fish smaller, posing significant threats to global food security and fishery productivity. • The research warns that the shift toward smaller fish species could worsen fishery losses by as much as 50%, impacting both commercial fishing industries and food availability worldwide. • The findings highlight the cascading ecological effects of climate change on marine ecosystems and underscore the urgency of addressing global warming to protect food systems.

• Scientists at Sanford Burnham Prebys Medical Discovery Institute developed TLPath, a new computational tool that infers telomere length—repeating DNA sections at chromosome ends that shorten with age—by detecting structural changes in cells captured in routine biopsy images. • The model successfully predicted telomere length more accurately than using patient age alone and could identify telomere length differences between individuals of the same chronological age, potentially transforming large-scale aging research. • Published in Cell Reports Methods, the findings enable researchers to measure an important aging metric quickly and cheaply without costly traditional tests, opening new opportunities to study telomere biology and human aging.

• Researchers from Skoltech have successfully used gene editing to double the number of grains produced per wheat spike, a breakthrough that could significantly increase crop yields. • The advancement addresses global food security concerns by enhancing wheat productivity through targeted genetic modifications. • This development represents a major step forward in agricultural biotechnology and sustainable food production methods.

• NASA's Astronomy Picture of the Day highlights NGC 1566, a grand design spiral galaxy located approximately 40 million light-years away in the constellation Dorado, known for its two prominent and graceful spiral arms traced by bright blue star clusters and red emission nebulas. • The galaxy's flaring center makes it one of the closest and brightest Seyfert galaxies, likely housing a central supermassive black hole affecting surrounding stars and gas, making it a prime target for Hubble Space Telescope observations studying star formation and supernovas. • NGC 1566 is among the most photogenic spiral galaxies in the universe, featuring a gorgeous face-on view and dark cosmic dust lanes that make it an ideal object for astronomical research and observation.

• A UC Riverside-led study analyzing thousands of samples from unrelated studies found that no places in the ocean remain completely untouched by human chemical impacts. • Researchers combined consistent, high-resolution mass spectrometry methods across multiple laboratories with computational tools to create a unified dataset revealing the extent of human chemical alterations to marine environments. • The study reveals significant data gaps, with heavy concentration in North America and Europe while the Southern Hemisphere and regions like Southeast Asia, India, and Australia remain largely understudied, limiting full understanding of global ocean impacts.

• Engineers at Washington University in St. Louis discovered that cells can sense far beyond the surfaces they touch through a process called "depth mechano-sensing," with clusters of normal epithelial cells detecting layers as far as 100 microns away by tugging on surrounding collagen fibers. • Individual cancer cells can probe about 10 microns ahead, while normal cell clusters working together can sense 10 times farther, helping cells decide where to migrate and providing new insights into cancer cell behavior. • The findings, published in PNAS, could reveal new targets to prevent cancer from spreading and advance understanding of how cancer cells move through the body.

• New York University Abu Dhabi team discovered clues of subsurface water on Mars in Gale Crater using NASA's Curiosity rover data, indicating habitability lasted longer than previously thought. • Ancient sand dunes hardened into rock billions of years ago after interacting with groundwater, confirmed by comparing Martian formations to UAE desert analogs. • Led by Dimitra Atri, the study published in Journal of Geophysical Research - Planets highlights underground sites as prime locations for past life evidence.

• Houston Methodist scientists identified TDP43 protein as a critical regulator of DNA mismatch repair, connecting it to ALS, frontotemporal dementia, and cancer risks. • Lead investigator Muralidhar L. Hegde, Ph.D., stated 'DNA repair is one of the most fundamental processes in biology' and TDP43's role has major implications for these diseases. • The peer-reviewed study, published in Nucleic Acids Research on March 15, 2026, was funded by NIH's NINDS and National Institute on Aging.