Advance

• The MajesTEC-3 clinical trial led by UAB researchers demonstrates that a new two-drug immunotherapy regimen can lead to long-lasting remission for multiple myeloma patients. • Over 83 percent of patients enrolled in the trial remain alive and progression-free three years after therapy, supporting approval of this potentially curative treatment. • The findings represent a significant advance for multiple myeloma, a blood cancer with limited treatment options historically.

• No. 3 seed Illinois defeated Big Ten rival Iowa 71-59 in the South Region final, earning a spot in Saturday's national semifinal against No. 2 seed Connecticut at 6:09 p.m. ET. • Freshman Keaton Wagler led with 25 points and was named Region Most Outstanding Player, while Andrej Stojakovic added 17 points. • Illinois outscored Iowa 20-8 after a 51-51 tie with 7:14 left, closing with an 8-0 run as Iowa failed to score in the final two minutes.

Measure that would fund homeland security but exclude money for ICE could conclude lengthy funding lapseAn end to the partial shutdown of the Department of Homeland Security (DHS) may be in sight, after Congress’s Republican leaders on Wednesday agreed to advance legislation that would fund the majority of the agency’s operations, with the exception of those involved in immigration enforcement.The pact may conclude the longest such funding lapse in US history, which last month caused security lines to stretch for hours at some airports as employees of the Transportation Security Administration (TSA), a subagency of DHS, quit their jobs or called out of work after going weeks without pay. Continue reading...

• Soligenix's HyBryte for cutaneous T-cell lymphoma (CTCL) has a second Phase 3 trial underway with enrollment of approximately 80 subjects, interim analysis in Q2 2026, and top-line results in H2 2026. • Previous Phase 3 trials showed statistical significance in primary endpoints across multiple cycles, following FDA NDA submission and RTF letter. • The program targets unmet needs in rare dermatological cancers with ongoing FDA discussions for development path.

• President Trump rescinded Biden-era executive orders, directing federal agencies to terminate all DEI and environmental justice roles, offices, and equity-focused programs. • Funds are prohibited for promoting gender ideology, mandating 'sex' as male or female in documents like passports, eliminating 'X' gender options. • OMB and OPM are coordinating hiring changes, ending chief diversity officer positions and reinstating bans on racial bias training.

• House Speaker Mike Johnson declined to commit Friday to passing the Senate-approved DHS funding bill, which excludes ICE and CBP funding amid ongoing agency shutdown. • Conservative Freedom Caucus Chair Andy Harris opposes the deal, demanding restoration of immigration enforcement funds and attachment of SAVE America Act voter ID legislation before returning to Senate. • Johnson faces challenges passing via party-line rule or two-thirds suspension vote, risking backlash from hard-liners and Democrats.

• Top-seeded Arizona defeated Arkansas 109-88 in the Sweet 16 on March 27, shooting nearly 64% from the field to reach the Elite Eight for the first time since 2015. • Freshmen Brayden Burries and Koa Peat each scored 21 points, while Arkansas' Darius Acuff Jr. led his team with 28 points. • The win extends Arizona's winning streak to 12 games, positioning them one victory from their first Final Four in 25 years.