Alzheimer

• Researchers at Johns Hopkins University published findings in Nature Medicine on March 20 showing a blood test can detect Alzheimer's pathology 15-20 years before symptom onset with 94% accuracy. • The test measures phosphorylated tau and amyloid-beta levels and was validated in 2,100 cognitively normal participants followed for up to 12 years in multiple longitudinal cohorts. • Early detection could enable preventive interventions during the asymptomatic stage, potentially delaying or preventing cognitive decline in the 6 million Americans living with Alzheimer's disease.

• A new coalition led by University of Maryland professor John Moult, creator of the Critical Assessment of Structure Prediction (CASP), is launching an initiative to assess the reliability of Alzheimer's literature and identify which experiments can be trusted. • The effort aims to evaluate competing hypotheses about the APOE4 gene's role in Alzheimer's by examining experimental conditions, statistical analyses, and data quality across human, mouse, and cell studies. • The approach leverages large language models to apply objective measuring standards to scientific literature, similar to how CASP's blind challenge methodology validated DeepMind's AlphaFold tool, which contributed to the company's 2024 Nobel Prize in Chemistry.

Persistent inflammation in the gut, lungs and skin might lead to Alzheimer's disease, but lifestyle choices - from getting vaccinated to eating well - can keep inflammation under control