Gut

• An NIH-funded mouse study shows chronic colitis induces long-lasting epigenetic changes in gut stem cells, boosting AP-1 transcription factor activity and tumor growth potential. • Researchers analyzed over 52,000 cells, finding damage memories persist more than 100 days after inflammation ends, heritable across new cells. • The findings from Broad Institute scientists explain how sustained inflammation elevates colorectal cancer risk through dynamic epigenome alterations.

Today show co-host appeared in pretaped interview as her mother, Nancy Guthrie, has been missing for seven weeksSavannah Guthrie, the co-host of NBC’s Today show, has described her family’s ordeal as “agony” in her first interview since her mother’s disappearance more than seven weeks ago.“Someone needs to do the right thing. We are in agony. We are in agony. It is unbearable,” Guthrie said through tears in a preview of the pretaped interview with her co-host, Hoda Kotb, which previewed on Wednesday. Continue reading...

• Carrie Wolinetz warns in a March 24, 2026, viewpoint that firing credible scientists and dismantling U.S. health agencies poses severe risks to public health and scientific integrity. • The article highlights the broader implications for national research capacity amid ongoing policy shifts affecting federal science funding and personnel. • Such actions undermine peer-reviewed findings and U.S. leadership in health research, potentially delaying responses to emerging threats.

Today show host released new statement asking for help in locating mother, 84, now missing for seven weeksSavannah Guthrie and her family have released a new statement about their missing mother, urging Tucson, Arizona, residents to come forward with potential clues about 84-year old’s Nancy Guthrie’s whereabouts.In their statement on Sunday, the NBC Today show host and her siblings said: “We continue to believe it is Tucsonans, and the greater southern Arizona community, that hold the key to finding resolution in this case. Someone knows something. It’s possible a member of this community has information that they do not even realize is significant.” Continue reading...

March is Colorectal Cancer Awareness Month, with the CDC identifying colorectal cancer as the third most common cancer for both men and women in the United States. Cleveland Clinic registered dietitian Julia Zumpano emphasized that a healthy, diverse microbiome reduces inflammation, which is linked to increased colorectal cancer risk, and recommended dietary changes including high-fiber foods like whole grains, fruits, vegetables, and legumes alongside fermented and probiotic foods such as yogurt and kimchi. In addition to dietary modifications, regular physical activity has been shown to reduce colorectal cancer risk, though individuals experiencing persistent gastrointestinal symptoms should seek medical attention. The preventive approach focuses on gradual lifestyle transitions rather than overwhelming dietary overhauls.

The Alzheimer’s field is being turned on its head as mounting evidence points to the disease beginning outside the brain many years before symptoms start. This may mean we have to totally rethink how we approach preventing and treating the condition