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Lipfendra can be taken in conjunction with or an alternative to statins, the most prescribed medication in the USSign up for the Breaking News US newsletter email The drug giant Merck on Thursday announced it had received FDA approval for a daily pill that can be an alternative to statins for treating high LDL levels, or so-called bad cholesterol. The new pill, Lipfendra, is a version of a drug called a PCSK9 inhibitor.For decades the go-to therapy to treat high cholesterol levels has been statins, the most prescribed medication in the US. But statins come occasionally with side effects like muscle aches and they sometimes don’t drop cholesterol levels enough to meet recommended levels. Continue reading...

• Scientists have developed a new theoretical framework that expands the application of thermodynamics to dynamic, ever-changing black holes. • Previously, these laws were primarily applicable to perfectly stable black holes, limiting the scope of astrophysical models. • This upgrade is significant as it allows for a deeper understanding of complex phenomena, including black hole mergers and the process of evaporation.

• UN aid coordination office OCHA reported on Tuesday that humanitarians are facing significant challenges delivering aid to communities near the “Yellow Line” in northern Rafah, Gaza. • The announcement follows a consultation between the UN and representatives from 17 displacement sites, which currently host approximately 3,000 families. • These disruptions to humanitarian services are linked to reported movements of Israeli forces within the region, complicating the delivery of essential supplies.

Home secretary expected to amend Immigration Act but hurdles remain if Pakistan continues to refuse to take Shabir Ahmed backShabana Mahmood is planning to change the law so the government can move towards deporting the ringleader of the Rochdale grooming gang.The home secretary is expected to amend the 1971 Immigration Act, which prevents Shabir Ahmed from being removed from Britain. Continue reading...

• Astronomers have released the largest gravitational wave catalog to date, adding 161 new black hole collisions to bring the total number of detections to 390. • The new data includes the clearest gravitational wave signal ever recorded and the most precise location tracking for a black hole merger. • These findings are significant as they provide growing evidence that certain black holes are "second-generation" objects formed from previous mergers.

• The U.S. Supreme Court has allowed the termination of Temporary Protected Status (TPS) for nationals from Haiti and Syria. • This decision removes the legal protections that previously permitted these individuals to live and work legally within the United States. • Experts warn that the loss of these workers could create significant labor shortages, potentially damaging both local and national economies.

Success of statins and blood-pressure drugs hailed as researchers find some people with obesity were ‘better off’Many adults who are obese have “indistinguishable” cholesterol and blood pressure levels compared with those with a healthy weight, largely because of the use of statins, according to a study.In some cases, people with obesity were “better off” than those of a healthy weight, researchers added. Continue reading...

• Kemi Badenoch has launched a sharp political attack on Andy Burnham, criticizing what she describes as his "mistaken beliefs." • The confrontation centers on Badenoch challenging Burnham's political ideology and vision before he could potentially seek the premiership. • This clash highlights the deepening ideological divide between the Conservative and Labour leadership styles within UK politics.

• Wholesale inventories remained steady with a reported figure of 0.3%, precisely matching the projections set by market analysts. • This stability indicates that wholesalers are maintaining a balanced approach to inventory management amidst a cautious economic environment. • The alignment between the actual data and forecasts suggests that current supply chain and stock levels are meeting market expectations.

• This week's science highlights include a massive earthquake that may have physically shifted the position of Japan. • Researchers have achieved a "cosmic first" by using observations to study black-hole horizons, a feat previously considered science fiction. • Theoretical physicist Sizheng Ma of the Perimeter Institute in Canada emphasized the significance of transitioning these observations into actual scientific practice.

• US wholesale inventories rose by 0.3% in May 2026, aligning exactly with market expectations. • Retail inventories grew at a faster rate of 0.6% during the same period, suggesting a divergence in stock accumulation between the two sectors. • This upward revision in wholesale inventories is expected to provide a modest boost to Q2 GDP estimates, as inventory growth contributes positively to overall economic growth.

• A study by researchers, including Professor Mariassunta Giannetti of the Stockholm School of Economics, warns that simplifying bank regulations in the U.S. and Britain could inadvertently weaken financial stability. • The research suggests that while complex rules are harder to manage, they are more difficult to circumvent, whereas simpler rules are more likely to be "gamed" by lenders. • This finding is significant because it indicates that banks may shift risks elsewhere in the system to bypass simplified regulations, even if those rules appear strict on paper.

Australian woman Leah Stewart no longer in critical condition but doesn’t yet have use of her handA woman who was attacked by a shark at Sydney’s Coogee’s beach is no longer in a critical condition and “remembers the whole event in detail”, her brother has said.Leah Stewart’s brother, Joshua, provided the update on a fundraising site on Thursday, writing that it was “amazing to hear from her so much sooner than anyone expected” and she had been “overjoyed” to see her daughter for the first time since the incident almost two weeks ago. Continue reading...

State government and consortium strike deal to complete M6’s twin tunnels with minister insisting there is ‘no extra cost to NSW taxpayers’Get our breaking news email, free app or daily news podcastTunnelling on Sydney’s $3.1bn M6 project, dubbed the potentially “unbuildable motorway”, will resume after the state government struck a deal with contractors, ending a two-year stalemate during which works were halted.Under the terms of the new agreement, the private consortium will absorb the costs of finishing the tunnels, limiting the financial hit to taxpayers. Continue reading...

Jamie Varley jailed for life and partner John McGowan-Fazakerley jailed for 19 years over death of Preston DaveyA secondary school teacher has been jailed for life for sexually abusing and murdering the baby boy he was adopting with his partner.Jamie Varley, 37, was sentenced to a whole life order by a judge on Thursday for abusing and killing 13-month-old Preston Davey. It means he will stay in prison for the rest of his life and never be eligible for parole, Mr Justice Turner said. Continue reading...

US president left last meeting early, but world leaders aim to end Ukraine war and push for resolution in Gaza and IranEmmanuel Macron, the host of the G7 summit in Évian-les-Bains, has framed an agenda to make it as palatable as possible to his guest of honour, but the French president has no idea if Donald Trump, a haphazard summit attender, will last the full three days – or disrupt the proceedings every hour he stays.The US president quit the last G7 summit in Kananaskis, Canada, early to work on the Iran conflict, and this year, plus ça change, Iran may also draw presidential attention. For good measure, he insulted this summit’s host before leaving Canada last year, describing Macron as “publicity seeking” and adding: “Purposefully or not, Emmanuel Macron always gets it wrong.” Continue reading...

• NASA's James Webb Space Telescope has uncovered new evidence regarding "little red dots," mysterious objects discovered in 2022 that emerged roughly 600 million years after the Big Bang. • By analyzing the spectrum of a specific red dot, researchers are now strengthening the "black hole star" hypothesis to explain these abundant early-universe phenomena. • This discovery is significant as it helps scientists solve a complex cosmic puzzle regarding the nature and composition of objects in the infant universe.

• Astronomers using the James Webb Space Telescope (JWST) have discovered evidence that the mysterious "little red dots" observed in the early universe may be black hole stars. • While many such objects have been spotted, researchers found a specific instance where all necessary pieces of evidence aligned to support this classification. • This discovery is significant as it helps scientists understand the nature of these enigmatic objects and the evolution of the early cosmos.

• Theoretical physicists are exploring the holographic principle, a theory suggesting that the three-dimensional universe may actually be a projection of two-dimensional information. • The concept stems from the study of black holes, where information about falling matter appears to be stored on the event horizon's surface rather than within the volume. • This hypothesis is significant because it attempts to reconcile general relativity with quantum mechanics, potentially providing a unified framework for understanding gravity and spacetime.

Video of figures clambering in and out of manholes sparks intrigue – and comparisons with crime-fighting turtlesIt started in early May. Under cover of darkness, three people pried open a manhole cover in Queens, New York, and clambered down into the sewer.The incident might have gone unnoticed, but the subterranean quest, which was caught on film, captured New Yorkers’ interest when it happened again, and again, in the same month, with two other groups filmed making their way in and out of the sewer system in Brooklyn. The string of events have seen those involved dubbed “mole people” by the local press. Continue reading...

• Astronomers have discovered powerful winds emanating from Sagittarius A*, the supermassive black hole located at the center of the Milky Way galaxy. • The discovery concludes a 50-year search by scientists attempting to find direct evidence of these galactic outflows. • This finding is significant because it provides critical insight into how black holes influence their surrounding environments and regulate galaxy evolution.

• Israel's military operations, which began with the destruction of Gaza, have expanded into Lebanon, Iran, and the Gulf region. • The escalation is being sustained through significant financial support and arms shipments provided by the United States. • This expansion threatens to transform a regional conflict into a state of prolonged international disorder and global chaos.

• Astronomers are observing a massive black hole actively tearing apart the galaxy NGC 1266, a lesser-known lenticular galaxy. • The process involves the black hole consuming surrounding matter, which triggers powerful outflows of gas and energy. • This event is significant because it allows researchers to study the "life stories" of lenticular galaxies and how supermassive black holes influence galactic evolution.

Investigation follows circulation of videos showing groups climbing out of sewer systems across the city at nightNew York police are investigating a bizarre mystery involving groups of people emerging from the city’s manholes in recent weeks.The investigation follows the circulation of multiple social media videos showing people climbing out of sewer systems across the city, all in the middle of the night. Continue reading...

• NASA’s James Webb Space Telescope has identified a massive black hole that appears to have formed before its host galaxy. • This discovery challenges the traditional scientific consensus that galaxies form first, with black holes later developing from the collapse of massive stars within them. • The finding is significant because it suggests a different evolutionary path for the early universe, where black holes may act as seeds for galaxy formation.

• The James Webb Space Telescope has discovered an ancient black hole that appears to have formed before its host galaxy, challenging existing astronomical models. • These findings stem from observations of "Little Red Dot" galaxies, which are extremely distant and ancient objects in the early universe. • The discovery represents a "paradigm shift" for scientists, as it forces a total revisiting of classical scenarios regarding how black holes and galaxies co-evolve.

Marsh Street has been cited as Bristol’s worst for potholes. But it’s just one of many crumbling roads in Britain as councils face repairs backlogs and lack of fundsMarsh Street in the historic centre of Bristol is a modest little stretch of road with an office block at one end, a Thai restaurant at the other, and an almighty mess in between.Along its length of 200 metres or so, the tarmac surface of the road is pockmarked with many dozens of cracks, patches, divots and holes. In some spots where the surface has worn away, three or more layers of road structure are exposed beneath. What is a bouncy enough ride in a bus or car is even more of an assault course for cyclists, a number of whom weave carefully down its length as they cut through the city centre. Continue reading...

Officials say sinkhole discovered at about 11am as emergency crews rush to complete repairsA sinkhole was discovered at New York’s LaGuardia airport on Wednesday, shutting down a runway while emergency crews sought to determine its cause and how to fix it.In a post on X, LaGuardia, which handles domestic travel, said the sinkhole had been discovered at about 11am “near runway 4/22” while the airport’s operator was conducting its daily morning inspection. Continue reading...