Study Finds Spironolactone Increases Hospitalizations in Heart Failure Patients at ACC.26 Conference
β’ The SPIRIT-HF study, presented at ACC.26 in New Orleans (March 28-30, 2026), found that spironolactone increased hospitalizations and serious adverse events in patients with HFpEF (heart failure with preserved ejection fraction) or HFmrEF (mildly reduced ejection fraction). β’ Results raise significant safety questions about the drug's efficacy in these patient populations, potentially challenging current treatment protocols. β’ The findings were presented to cardiologists and cardiovascular specialists at the American College of Cardiology's annual conference, the largest gathering of heart disease specialists.
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