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• Helus Pharma has completed enrollment ahead of schedule for the Phase 3 APPROACH study, which evaluates HLP003 as an adjunctive treatment for Major Depressive Disorder. • The company is continuing enrollment for EMBRACE, a second pivotal study within the Phase 3 PARADIGM Program, while rolling participants into the EXTEND study for long-term safety data. • This milestone is significant as HLP003 has previously been granted Breakthrough Therapy designation, signaling its potential to provide substantial improvement over existing therapies.

• The World Peace Forum in Islamabad recently recognized Pakistan's proactive regional diplomacy, with international speakers praising the country's efforts to foster stability. • Senator Mushahid Hussain urged the establishment of a new "World Order" led by the Global South to challenge existing geopolitical imbalances. • The forum emphasized the need for inclusive global governance to better represent the interests of developing nations in international decision-making.

PM Mark Carney says Canada has made proposals to resolve dispute as tariffs are due to be imposed on wide range of goodsSign up for US Breaking News emailHello and welcome to the US politics live blog.Canadian prime minister Mark Carney has said that Ottawa is ready to deepen trade talks with the United States, after US president Donald Trump ordered fresh tariffs targeting Canada.Canadians across the political spectrum united in anger at Trump. “If these tariffs proceed, Canada should respond tariff for tariff, dollar for dollar,” Ontario premier Doug Ford said. Canada’s prime minister, Mark Carney, called the tariffs a “direct violation” of the US-Mexico-Canada free trade agreement Trump negotiated. Canada’s Conservatives called the tariffs “another unacceptable and unjustified attack on Canadian workers and our businesses,” adding: “Canadians are not a punching bag.” The leader of Canada’s New Democrats called them “the latest economic grenade thrown over the border by an out of control President who has lost touch with reality.”Ilya Somin, a professor of law at George Mason University who helped file the successful challenge to Donald Trump’s “liberation day” tariffs, points out, the president’s new 50% tariffs on Canadian imports “are based on Section 338 of the notorious 1930 Smoot-Hawley tariff legislation, which severely exacerbated the Great Depression.”Nancy Mace, a Republican congresswoman from South Carolina, announced on Monday that she is not entering the race to replace the late senator Lindsey Graham in the snap Republican primary next month. Continue reading...

• Israeli government ministers, including Itamar Ben Gvir and Bezalel Smotrich, joined thousands of settler activists in a march through a closed military zone toward the Gaza border. • Minister Ben Gvir condemned judicial interventions as "trampling the will of the people," vowing that a future right-wing government will dismantle the "deep state" and overhaul the judicial system. • Finance Minister Smotrich highlighted a pattern of judicial freezes, specifically citing injunctions against legislation regarding the arrest of draft dodgers.

Tom Homan’s comments come amid scrutiny over federal immigration agents’ fatal shooting of two men in six daysUS Immigration and Customs Enforcement (ICE) will require its officers to record vehicle stops with at least one body camera, said Tom Homan, the Trump administration “border czar”, on Sunday. The action comes as the agency is under renewed scrutiny after ICE officers fatally shot two men earlier this month.“They exonerate more law enforcement than they convict, and I want officers to wear body cameras because I want the American people to see what the ⁠officers saw when they took that action,” Homan said on the Fox & Friends Weekend program. Continue reading...

Car chase began in Queensland after report of armed man on Gold Coast late on Saturday, police sayFollow our Australia news live blog for latest updatesGet our breaking news email, free app or daily news podcastNew South Wales police have declared a “critical incident” after a man died following a police pursuit in the northern rivers area, hours after the same man allegedly evaded Queensland police while armed with a gun.The 25-year-old from Queensland was found unconscious at the wheel of a vehicle, which had driven down an embankment south of Murwillumbah, about 2am on Sunday, NSW police said. Continue reading...

• Delhi Police shifted activist Sonam Wangchuk from the Jantar Mantar protest site to VMMC and Safdarjung Hospital on Saturday. • The move follows a High Court order and occurs after Wangchuk completed 20 days of an "indefinite" hunger strike. • The protest was aimed at pressuring the state, though authorities characterized the strike as an attempt to hold the government to ransom.