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Kyle Diamantas, a top official at the agency, will reportedly replace Makary and serve as acting FDA commissionerSign up for the Breaking News US newsletter emailMarty Makary resigned from his position as commissioner of the US Food and Drug Administration (FDA) on Tuesday, concluding a 13-month tenure at the regulatory agency that frequently drew the ire of the White House, Congress, industry and the public, according to US media reports.Kyle Diamantas, who previously worked as the top food official at the agency setting the strategic direction and operations for food policy in the US, has been reported as Makary’s acting replacement, per Politico, who first reported the resignation and Makary’s replacement. Reuters and NBC News also reported on Makary’s resignation. Continue reading...

In-depth study also reveals patients from black African and Caribbean backgrounds are less likely to receive timely carePeople from black backgrounds in England are twice as likely to experience strokes as their white counterparts, while also being less likely to receive timely care, according to the largest study of its kind.The study, conducted by researchers at King’s College London and presented at the European Stroke Organisation conference, analysed 30 years of stroke incidents from the South London Stroke Register, one of the longest-running population-based stroke registers in the world. Continue reading...

Extreme weather likely to continue after devastating homes and endangering millions in US south and midwestAt least one person was killed after a very powerful tornado struck northern Texas on Saturday night, as extreme weather continued to devastate homes and put millions across the south and midwestern US at risk, with wildfires also raging on in parts of Georgia.Officials from Wise county in Texas said the storm reached the area at around 10pm and caused significant damage across multiple neighborhoods. In addition to the confirmed death, six people were treated or transported by emergency responders to be treated for storm-related injuries. Continue reading...

Accumulations of up to 3cm deep reported as severe thunderstorms also bring heavy downpours to central Italy This week has seen severe thunderstorms affect the Mediterranean. On Monday, a surface low-pressure system in the Mediterranean in conjunction with an upper air cut-off low, lead to thunderstorms over north Africa. Their intensity was aided by the hot precursor conditions.Algeria and Tunisia were notably affected by the thunderstorms, with some hail accumulation layers as a result. When so much hail forms, it starts to lay down sheets of hail, covering the ground like snow. Hail accumulations of up to 3cm were reported in Oum Ladjoul and Hammam Sokhna in Algeria, and there were hailstones of up to 3cm in diameter fell in Makthar, Tunisia. Thunderstorms continued in the region through the following day, with further hail accumulations, notably in Ouled Bousmir, Tunisia, where there was a layer of about deep. Continue reading...

South-east England could reach 24C as short period of settled weather replaces rain and 70mph windsParts of the UK are set to enjoy the warmest temperatures of the year so far in the wake of Storm Dave, which caused widespread damage and disruption over the Easter weekend.London and south-east England could reach temperatures of 21C or 22C on Tuesday, rising to 24C on Wednesday, while Manchester could hit 20C, say forecasters, as a short period of settled weather replaces the rain and 70mph winds that battered parts of northern England, Scotland, Wales and Northern Ireland. Continue reading...

Springs fire, which had spread quickly by windy conditions, at least 45% contained on Saturday, say fire officialsCalifornia fire protection crews on Saturday were getting a handle on the wildfire that broke out the previous evening in Riverside county, fanned by high winds that quickly spread the flames to more than 4,100 acres.The Springs fire, about 64 miles (103km) east of Los Angeles, was at least 45% contained on Saturday, a fire department spokesperson said. It was 25% contained late on Friday evening. Continue reading...

Storm Dave expected to cause Easter weekend travel disruption, though warm weather could return next weekStorm Dave is expected to cause travel disruption this Easter weekend, with warnings for heavy snow and gale-force winds issued across northern parts of the UK, but a reprieve from the cold snap could be on the way, with temperatures forecast to reach the mid-20s next week.The Met Office has issued a yellow severe weather warning in Scotland for heavy snow and blizzards causing some travel and power disruption. Up to 30 centimetres of snow could fall. An amber weather warning for wind has been issued for parts of northern England, Scotland and Wales on Saturday evening. Continue reading...

Plans would prevent the return of hundreds of thousands of residentsMiddle East crisis live – latest updatesIsrael said on Tuesday that it will occupy wide swathes of south Lebanon and destroy the homes along the border to prevent the return of some 600,000 residents, prompting concerns of long-term forced displacement.Israel’s defence minister, Israel Katz, said that it will occupy the area under the Litani River, some 19 miles from the Israel-Lebanon border, as part of its so-called buffer zone inside southern Lebanon when fighting with Hezbollah ends. Continue reading...

New Mexico governor calls order ‘not serious’ as south-eastern counties note divisions with Democratic Santa FeThe speaker of Texas’s house of representatives says he is entertaining the idea of expanding the state by annexing some New Mexico counties.Dustin Burrows, who has been the chamber’s speaker since 2025, ordered a state legislative committee on 26 March to look into the legal and economic options to add “one or more contiguous counties” of New Mexico to the state of Texas. Continue reading...

Almost 60 injured and three others missing after blaze breaks out at building in DaejeonA fire at a car parts factory in South Korea has killed 11 people and injured almost 60 others.Firefighters said the death toll could rise further. Rescuers were using dogs to search the wreckage of the three-storey building for three people who were still missing. Continue reading...

Karachi particularly badly affected with 18 people killed, more than 50mm of rain and winds gusting up to 60mphUnseasonally wet weather struck southern Pakistan and north-west India on Wednesday, as heavy rain rolled in from the west, accompanied by thunderstorms, hail, and strong winds.Karachi, Pakistan’s largest city, was particularly badly affected, locally recording more than 50mm of rain with winds gusting up to 60mph. Walls, buildings, and a pedestrian bridge collapsed, with flooding and power outages across the city. At least 18 people were killed and several more injured, many by structural collapses, with other deaths attributed to a fallen tree and a lightning strike. Continue reading...

• Democrats laying groundwork for major U.S. health care reforms amid political shifts in Washington. • NIH's Bhattacharya commits to full budget spending; top FDA official announces exit. • Moves signal potential policy battles over research funding and regulatory changes.

Exclusive: finding out who owns land will become simpler under plans to make the best use of green spaces and hit net zero targetsFinding out who owns land in England is to become much simpler because a paywall will be lifted from large parts of the Land Registry, the government is to announce.A small number of landowners control the majority of land but finding out who owns what is difficult to piece together, even for government departments, owing to the way the Land Registry operates. Freeing up access will make it easier to determine ownership of key areas, such as river catchments, grouse moors and peatland. Continue reading...