Protein

• Oregon Health & Science University researchers revealed a previously unknown system of directed fluid flows within cells that rapidly transport essential proteins to the cell's leading edge, published today in Nature Communications. • The breakthrough emerged from an accidental observation during a neurobiology course when scientists used lasers to track protein movement and discovered an unexpected wave of soluble actin being pushed forward rather than drifting randomly through the cell. • The discovery fundamentally reshapes understanding of cell migration, cancer metastasis, and wound healing by revealing that cells use active internal mechanisms rather than passive diffusion to position critical proteins.

• Researchers led by Professor Silvia von Karstedt discovered that loss of Caspase 8 protein in small cell lung cancer triggers inflammation promoting tumor growth and spread. • The study, published in Nature Communications on March 25, 2026, shows this loss reprograms cancer cells into an aggressive neuron-like state associated with relapse. • Findings from the CECAD Cluster of Excellence explain the cancer's notorious aggressiveness and poor prognosis.

• Houston Methodist scientists identified TDP43 protein as a critical regulator of DNA mismatch repair, connecting it to ALS, frontotemporal dementia, and cancer risks. • Lead investigator Muralidhar L. Hegde, Ph.D., stated 'DNA repair is one of the most fundamental processes in biology' and TDP43's role has major implications for these diseases. • The peer-reviewed study, published in Nucleic Acids Research on March 15, 2026, was funded by NIH's NINDS and National Institute on Aging.