Prove

• The U.S. FDA has approved ensitrelvir (Xocova), an oral antiviral developed by Shionogi, for the post-exposure prevention of COVID-19. • The medication is authorized for use in individuals aged 12 years and older who have been exposed to the SARS-CoV-2 virus. • This approval is significant as Xocova becomes the first and only oral medication specifically authorized to reduce the risk of infection after a known exposure.

• The FDA has approved Shionogi’s Xocova (ensitrelvir) as the first oral therapy designed to prevent Covid-19 after a person has been exposed to the virus. • The approval follows the Scorpio-Pep trial involving 2,387 participants aged 12 and older who were asymptomatic but had been exposed to a symptomatic household member. • The drug works by inhibiting viral replication, offering a critical new preventative tool for those who initiate treatment within 72 hours of their contact's symptom onset.

• The Global Environment Facility (GEF) has approved over USD 67 million in new funding to strengthen climate resilience in eight vulnerable nations. • Recipient countries include Bangladesh, the Democratic Republic of the Congo, Guinea-Bissau, Niue, Senegal, Solomon Islands, Sudan, and Togo. • This financial injection is critical for supporting Least Developed Countries and Small Island Developing States in managing biodiversity loss and climate-driven disasters.

• The FDA has approved the oral medication ensitrelvir for use as post-exposure prophylaxis (PEP) to prevent the onset of COVID-19 symptoms. • Approval follows phase 3 clinical trial data conducted between February 10 and July 10, 2022, across 92 sites in Japan, Vietnam, and South Korea, demonstrating efficacy against Omicron variants. • This development is significant as it provides a preventative option for individuals exposed to the virus in high-risk environments, including nursing homes, acute care facilities, and during travel.

• The FDA has approved ensitrelvir, an oral antiviral medication specifically designed to prevent COVID-19 after a person has been exposed to the virus. • Approval follows the phase III SCORPIO-PEP trial, which demonstrated that the drug reduced the risk of developing COVID-19 by more than half for individuals who were household contacts of an infected person. • This marks a significant shift in prevention strategy, though the medication is currently not approved for treating active COVID-19 infections within the U.S.

• Shionogi has received FDA approval for its protease inhibitor, ensitrelvir, specifically for use in the prevention of COVID-19. • This regulatory win follows a previous failure by the company to demonstrate the drug's effectiveness as a primary treatment for U.S. patients. • The approval is significant as it expands the available preventative options against the virus, leveraging a drug already approved in Japan.

Court decision that represents win for Republicans comes after lengthy battle over state’s congressional mapSign up for the Breaking News US newsletter emailAlabama can use a redrawn congressional map that eliminates one of the state’s two majority-Black districts in this year’s midterm elections, the US supreme court ruled in a 6-3 decision on Tuesday, another major blow to Black voters and a win for Republicans.The court’s emergency ruling is the most consequential decision it had issued since its landmark ruling in late April that struck down a critical provision of the Voting Rights Act. In that case, Louisiana v Callais, the court’s majority made it nearly impossible to win Voting Rights Act claims, saying that plaintiffs had to prove intentional discrimination. But on 26 May, a three-judge panel said the map Alabama wants to use for this year’s midterm was enacted with discriminatory intent. Continue reading...

• The HinduBusinessLine reports that a new Index of Industrial Production (IIP) was unveiled on Monday alongside the release of April's factory output figures. • This update represents a significant watershed in data reforms, utilizing a more granular and contemporary database to capture industrial activity. • The revamp is critical because it provides a more accurate reflection of current economic trends, serving as a superior guide for policymakers.

• Germany has approved a draft law expanding the cyber defense powers of the Federal Office for Information Security (BSI), the Federal Criminal Police Office (BKA), and the Federal Police. • The legislation authorizes these agencies to actively disrupt attacker infrastructure, including the ability to target systems located outside of German borders. • This move follows documented sustained cyber campaigns targeting government bodies, political parties, research institutions, and industrial companies, some of which are linked to state-affiliated actors.

• Unproven treatments, including ivermectin, vitamin D, and zinc, are being promoted on social media as cures for hantavirus following a recent cruise ship outbreak. • While vitamin D and zinc are known to support general immune regulation, there is currently no hantavirus-specific clinical evidence to support their use for this disease. • This trend mirrors the misinformation patterns seen during the COVID-19 pandemic, where therapeutic extrapolation led users to adopt unverified medical treatments.

Policy U-turn comes after rightwing nationalist government was swept from power in April after 16-year ruleEurope live – latest updatesPolice in Hungary have said they will allow next month’s Pride parade in Budapest to take place, signalling a reversal from last year when they sought to block the event on the orders of the government of the rightwing former prime minister Viktor Orbán.Last year’s march made headlines around the world after Orbán’s Fidesz party backed legislation – the first of its kind in the EU’s recent history – that created a legal basis for Pride events to be banned, citing a widely criticised need to protect children. Continue reading...

Treasury secretary says banknote would celebrate US’s 250th anniversary but Democrats vow to block moveThe White House is pushing Congress to approve a $250 bill bearing Donald Trump’s portrait, US treasury secretary Scott Bessent said, which would require changing longstanding federal law that prohibits any living person from appearing on US currency.Speaking from the White House at a news conference, Bessent said the bill would be in celebration of the country’s 250th anniversary of independence, and that the treasury has already started preparing for the possibility of the new currency. Continue reading...

• On Wednesday, May 27, Hungary's parliament approved legislation to maintain the country's membership in the International Criminal Court (ICC). • This move reverses a previous decision by Prime Minister Viktor Orban's government to withdraw from the court, which had been slated for 2025. • The reversal follows claims from Orban's administration that the ICC had become "political," leading to the initial push for exit.

• The German government has approved a draft law requiring streaming services and broadcasters to invest a minimum of 8% of their annual German revenues into local productions. • The bill establishes specific sub-quotas for German-language content, new productions, and investments directed toward independent producers. • This measure aims to strengthen the domestic media landscape by ensuring fair rights sharing and guaranteed financial support for local creators.

Some analysts question whether design of Luce, starting at $640,000, lives up to sportscar brand’s heritageFerrari’s share price has dropped after it revealed a long-awaited first electric vehicle, with a minimalist look created by former Apple design chief Jony Ive that departs from the Italian manufacturer’s petrol sportscars.The Luce, starting at $640,000 (£545,000), has a range of 329 miles (530km) thanks to its battery capacity of 122 kilowatt hours, the company said, with four motors that can accelerate from 0 to 100km/h in 2.5 seconds, with a top speed of more than 310km/h (193mph). Continue reading...

Reform UK leader claims ‘counter-espionage experts’ suggest state-sponsored hackers are behind the disclosure of £5m giftNigel Farage is under mounting pressure to provide evidence for his claim that a state-sponsored Russian hack was behind the disclosure of the £5m gift he received from the crypto billionaire Christopher Harborne.Reform UK claimed over the weekend that analysis of Farage’s phone by “counter-espionage experts” suggested that “Farage’s phone, email and bank accounts were compromised by hostile actors, almost certainly linked to Moscow, using spear phishing tactics”, before the Guardian revealed details of his undeclared gift last month. Continue reading...

One or two clauses yet to be clarified, Iran officials tell Pakistani mediators, after US says deal ‘largely negotiated’Middle East crisis: live updatesIran’s supreme leader and national security council still need to approve the proposed peace deal between Tehran and Washington, Iranian officials said on Sunday.One or two clauses in the proposed peace deal between the US and Iran must be clarified to Iran’s satisfaction before the memorandum of understanding can be sent to Iran’s supreme national security council and the supreme leader Motjaba Khamenei for ratification, Iranian officials said on Sunday, adding this had been conveyed to the Pakistani mediators. Donald Trump claimed on Saturday that a peace deal with Iran “has been largely negotiated”, after calls with Pakistan, Gulf allies and Israel. Continue reading...

Exclusive: Move to establish board comes after criticism that Lammy’s plan to slash jury trials will lead to increase in racial and class biasDavid Lammy and the most senior judge in England and Wales are drawing up plans to accelerate the recruitment of minority ethnic and working-class solicitors into the judiciary.A new judicial and legal diversity board, chaired by Lammy, who is the first black lord chancellor, and Sue Carr, the lady chief justice, has met for the first time to discuss removing barriers for diverse candidates attempting to join the judiciary. Continue reading...

Approval marks key step forward for project dubbed ‘Arc de Trump’, which will be near Arlington National CemeteryThe Commission of Fine Arts on Thursday approved designs for Donald Trump’s proposed 250-ft triumphal arch in Washington DC.The vote on Thursday by the panel, which is made up of Trump appointees, marks a key step forward for the project. Next month, the proposed design is set to be reviewed by the National Capital Planning Commission, another federal panel that oversees planning for federal buildings and land. Continue reading...

• Thailand’s cabinet approved new borrowing of 200 billion baht, or $6.13 billion, to support a consumer subsidy scheme, Finance Minister Ekniti Nitithanprapas said Tuesday. • The package is part of the government’s effort to cushion households from higher costs linked to the Middle East conflict and broader economic pressure. • The decision matters because it shows Bangkok is using fiscal support to stabilize living costs and shore up demand at a fragile moment for the economy.

• Federal Reserve Governor Michael Barr said on Wednesday that banks and fintech firms are increasingly using transaction-account data, AI-assisted analysis and behavioral science to measure customers’ financial health. • Barr said these tools let institutions move beyond simply expanding access and instead design products and outreach that can produce “measurable improvement” in outcomes for consumers. • The speech matters because it signals continued Fed interest in responsible innovation, data-driven underwriting and consumer protection as lenders adopt more granular, near-real-time metrics.

President claims planned Tehran attack postponed to allow talks to continue – but no indication peace plan is imminentAs he seeks an exit from the Iran war, Donald Trump is increasingly outsourcing his policymaking to US allies in the Middle East, while the White House appears unable to find a simple way to end the fighting and reopen global shipping lanes held by Tehran.In Trump’s telling, the “dealmaker-in-chief” has maintained a consistent policy toward Iran aimed at preventing Tehran from obtaining a nuclear weapon, leveling threats and incentives to reach a new deal that would also open the Strait of Hormuz. Continue reading...

If he stands in Makerfield there will also need to be a mayoral contest to replace him in Greater ManchesterLabour’s national executive committee has approved Andy Burnham’s request to stand in the candidate selection process for the upcoming Makerfield byelection, paving the way for the Greater Manchester mayor to return to parliament.Burnham still has two more years of his term as mayor, meaning that if he stands there will need to be a mayoral byelection. Under Labour rules, sitting mayors need NEC approval to stand for Westminster. He would also need to be formally selected Continue reading...

• Iraqi lawmakers on Thursday approved a new government headed by businessman Ali al-Zaidi, ending months of deadlock in Baghdad. • The prime minister’s media office said parliament granted confidence to Zaidi’s cabinet, while the INA state news agency reported an absolute majority backed 14 ministerial nominations. • Zaidi, described as Iraq’s youngest prime minister at 40, was chosen on April 27 after growing pressure to restore a stable administration.

• A survey by Rutgers University and partner institutions found Americans disapprove of Trump administration policies targeting science and medicine by a margin exceeding 2-to-1, reflecting broad public opposition. • The polling data indicates significant public concern about the administration's approach to scientific research funding and medical policy implementation. • The survey results underscore ongoing public health and science policy controversies during the current administration's tenure.

Outgoing health secretary declares Labour’s ‘plan for the NHS is working’ as hospitals hit key targetHospitals in England have hit a key target for improving the time it takes patients to get treatment, which prompted Wes Streeting to declare that Labour’s “plan for the NHS is working” before departing as health secretary.Streeting had told the NHS to ensure that hospitals treated at least 65% of patients within 18 weeks by the end of March. New figures NHS England published today showed that hospitals did so, treating 65.3% on the NHS waiting list within that timeframe in March. Continue reading...

• A federal judge granted final approval to a $303 million class-action lawsuit settlement against the NCAA for former volunteer coaches. • The payout addresses compensation issues for volunteer coaches in Big 12 Conference programs and beyond. • This resolution provides financial relief to affected coaches and underscores ongoing legal pressures on the NCAA amid evolving college sports economics.

Facility would require more power than entire state uses and suck up vast amount of water in drought-stricken areaA plan to create one of the world’s largest datacenters, a gargantuan project spanning an area more than twice the size of Manhattan, has provoked a furious public backlash in Utah amid concerns over its vast energy use and impact upon the state’s stressed water supplies.The Stratos artificial intelligence datacenter footprint will cover more than 40,000 acres (62 sq miles) over three sites in Box Elder county in north-western Utah. The facility will require about 9GW of power, which is more than the entire state of Utah currently consumes, and suck up a significant amount of water in an area that has been hit by severe drought in recent years. Continue reading...