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• Researchers have identified 36 risk genes through rare-variant sequencing, uncovering shared biological pathways associated with specific health conditions. • While the study provides critical insights into the genetic architecture of these diseases, the findings do not currently translate into a clinical diagnostic test. • This discovery is significant as it advances the understanding of how rare genetic variants contribute to disease risk and biological dysfunction.

• NASA has launched the Nancy Grace Roman Telescope into space to conduct advanced astronomical research. • The mission focuses on probing the mysteries of dark matter and dark energy, discovering new exoplanets, and studying stars. • This telescope is critical for expanding our understanding of the universe's expansion and the composition of distant galactic systems.

• Member states of the Shanghai Cooperation Organisation (SCO) convened for a summit in Bishkek, where they condemned sanctions and attacks targeting Iran. • The group asserted their "inalienable right" to develop, produce, and utilize atomic energy for peaceful purposes, arguing that restrictive measures are contrary to international law. • Representing 43% of the global population and 23% of the world economy, the SCO's stance signals a collective push for equitable and non-discriminatory international cooperation in nuclear research.

• NASA's Swift space telescope has resumed its science observations after a private rescue mission failed to boost its decaying orbit. • The nearly 22-year-old observatory is now focusing on maximizing its remaining operational time to study the cosmos. • This development is critical because the telescope's orbit continues to decay, meaning it will eventually re-enter Earth's atmosphere and be destroyed.

• Prime Minister Narendra Modi, Chinese President Xi Jinping, Russian President Vladimir Putin, and Pakistani PM Shehbaz Sharif gathered for a group photo at the Shanghai Cooperation Organisation (SCO) Summit. • During the event, PM Modi was observed briefly exchanging words with President Xi Jinping, marking a notable interaction between the two leaders. • The gathering is significant as it brings together the leaders of four major powers amidst complex geopolitical tensions and diplomatic challenges.

• Prime Minister Narendra Modi urged member states at the SCO summit to combat state-backed terrorism and eliminate "double standards" in global security. • The summit resulted in the approval of regulations for the SCO Universal Centre for Countering Security and a 2026-2030 action plan for developing regional ports and logistics centers. • Member states also agreed to establish regional data centers and computing capacities to further develop the artificial intelligence industry.

• The Shanghai Cooperation Organisation (SCO) concluded its summit with a strategic goal to position itself as a global powerhouse challenging Western dominance. • Representing nearly half of the world's population, the group aims to foster a multipolar future, though the summit highlighted significant internal disagreements and divergent national interests. • Turkish President Erdoğan described the SCO as a "complement to the UN," emphasizing Türkiye's commitment to resolving regional conflicts through diplomacy and dialogue.

• NASA is developing the Nancy Grace Roman Telescope as part of a broader strategy to expand cosmic exploration beyond the capabilities of the Hubble Space Telescope. • The mission aims to complement existing observatories by exploring the universe across a diverse spectrum, including infrared, visible, ultraviolet, X-ray, and gamma ray wavelengths. • This initiative matters because it allows scientists to uncover new mysteries of the universe that were previously invisible or inaccessible to single-wavelength telescopes.

First minister sets out his government’s agenda and defends policy described by industry groups as a ‘potty gimmick’John Swinney insisted on Tuesday he still planned to introduce a legally binding price cap on bread, milk and other essential food items in Scotland despite fierce opposition from farming and business groups.Unveiling the Scottish National party’s programme for government – the equivalent to the king’s speech – the first minister said he wanted to give “families greater peace of mind at a time of rising prices”. Continue reading...

Brother of former treasurer and premier faces questions about texts that appear to indicate he was aware of fast-tracking policy before it was announcedGet our breaking news email, free app or daily news podcastDid the former premier’s brother, Charles Perrottet, have prior knowledge of a Covid-era New South Wales government policy to introduce a fast track to approve major developments?Did he take steps to ensure that developments owned by the fugitive developer, Jean Nassif, were successful through the fast track? Continue reading...

• Georgetown Law professor Stephen Vladeck discussed the Supreme Court's decision to allow Donald Trump to proceed with a White House ballroom project. • The legal analysis focuses on the separation of powers and the constitutional implications of the Court's ruling on executive property use. • This case highlights the ongoing tension between executive authority and judicial oversight regarding federal resources and presidential projects.

• Prime Minister Narendra Modi emphasized that all global conflicts and wars should be resolved through diplomacy and dialogue rather than on the battlefield. • Speaking at the SCO Summit in Bishkek on September 1, the Prime Minister reiterated India's commitment to peaceful resolutions. • Modi specifically highlighted India's ongoing dedication to providing humanitarian assistance and supporting the development of the people of Afghanistan.

Youth club closures, unaffordable housing and social media cited as factors contributing to a sharp decline in wellbeingThe number of young people with no close friends has risen fivefold since 2014 as a result of growing up in a “bleak world” dominated by austerity, the pandemic and social media.New research paints a sobering picture of how 11- to 24-year-olds in England are increasingly lonely, isolated and “disconnected” from themselves, peers and wider society. Continue reading...

• NASA has launched the Nancy Grace Roman Space Telescope, named after the agency's first chief astronomer and first female executive. • The telescope is embarking on a multi-year mission to map the universe and investigate the mysteries of dark energy and dark matter. • In addition to deep-space exploration, scientists expect the telescope to discover thousands of new planets within our own galaxy.

• NASA is developing the Nancy Grace Roman space telescope, a powerful new instrument designed to explore nearly every facet of astrophysics. • The telescope's primary mission focuses on investigating dark matter, dark energy, and the search for alien planets. • Scientists are particularly anticipating "absolute surprises," hoping the telescope will discover previously unknown phenomena that cannot be predicted.

• NASA has launched the Nancy Grace Roman Space Telescope, which is now embarking on a three-month, million-mile journey to reach its final orbit. • The telescope utilizes a wide field of view combined with high-resolution infrared vision to survey vast areas of the sky and probe cosmic history. • This flagship mission aims to uncover the "darkest secrets" of the universe by studying dark matter, dark energy, and exoplanets outside our solar system.

In today’s newsletter: First minister John Swinney has pledged to put an end to violence against women and girls. But can he turn ambitious laws into real change?Good morning. Violence against women and girls, in all its myriad forms – physical and mental, blatant and insidious – is a global challenge. It reaches back through millennia and, lately, it has been turbo-charged by technology, which offers abusers new ways to shame, harass and monitor victims. What would it take to eradicate it?Scotland’s first minister John Swinney wants to find out. Today, he will set out his programme for government (the Holyrood equivalent of the King’s speech), and Swinney surprised many when he pledged to put ending violence against women at the heart of his government’s ambitions for the coming year and beyond.Nepal-Tibet | Rescue teams are working to reach more than 900 missing hydropower workers, who are thought to be trapped in underground areas in Nepal, after the devastating flash floods.Iran | The new US sanctions campaign is expected to push many Iranians into deeper poverty as food inflation soars.UK | The British Museum privately hosted Palantir founder Peter Thiel in a private viewing of the Bayeux tapestry, the Guardian understands.Slavery | Countries are legally obliged to consider reparations for the transatlantic slave tried, and address the legacy racial discrimination, a UN committee has said.US news | A Las Vegas jury has found former South Side Compton Crips gang leader Duane Keith Davis guilty of the murder of Tupac Shakur, bringing the case to a close nearly 30 years after the famous rapper was gunned down. Continue reading...

• The Supreme Court ruled on Monday to allow the White House and President Donald Trump to proceed with construction on a $400 million ballroom project. • The decision comes as a divided court permits the work to continue while ongoing lawsuits regarding the project are litigated. • This ruling ensures that the massive infrastructure project will not be halted by legal challenges in the immediate future.

Resignation comes after months of turmoil at Pentagon, from leaked investigation to ousting of senior officialsArmy Secretary Dan Driscoll has handed his resignation to Donald Trump, the White House said on Monday,The army official, who is second in line to defense secretary Pete Hegseth, had reportedly been eyeing an exit from the Pentagon amid apparent friction with the secretary. Continue reading...

• NASA has launched the Nancy Grace Roman Space Telescope, a powerful observatory designed to chart the stars and explore the "dark universe." • Astronomers will utilize the telescope's wide and deep field of view to hunt for new exoplanets and study dark energy and dark matter. • The mission honors the legacy of Dr. Nancy Grace Roman, a pioneer in astronomy who helped shape NASA's space science programs.

Equal Employment Opportunity Commission finds ‘reasonable cause to believe’ tech firm subjected workers spoke up about Palestine to hostile work environmentThe US Equal Employment Opportunity Commission, the agency tasked with enforcing federal anti-discrimination laws, has found that Cisco, the global tech company, probably violated the civil rights of Middle Eastern, Muslim and other company employees.The determination, reached earlier this summer, is believed to be the first by the federal agency finding a major company at fault in connection to pro-Palestinian advocacy that swept campuses and workplaces in recent years. Continue reading...

• India U19 secured a victory over Sri Lanka U19 in the 1st unofficial ODI of the 2026 tour, scoring 324/6 in 49.2 overs. • Sri Lanka U19 previously posted a total of 320/6, with notable contributions from Yashveer Goud (33 off 21) and Shavin Vinodh (13 off 8). • This result gives India U19 an early lead in the unofficial series, demonstrating strong batting depth and chasing capability.

• NASA has concluded its live coverage following the successful launch of the Nancy Grace Roman Space Telescope via a SpaceX Falcon Heavy rocket. • The telescope successfully separated from the rocket's second stage, marking the start of its journey into space. • This flagship mission is designed to conduct vast, deep surveys to study dark matter, dark energy, exoplanets, and distant galaxies at the edge of the observable universe.

• NASA has successfully launched its newest space telescope, a tour-bus-sized instrument designed to unravel cosmic mysteries. • The mission aims to identify more than 100,000 exoplanets beyond our solar system to expand our understanding of the universe. • To handle the massive volume of information, NASA is utilizing a cloud-based system called Roman Nexus to make raw data accessible to the general public.

• NASA and SpaceX are preparing to launch the Nancy Grace Roman Space Telescope aboard a Falcon Heavy rocket. • The launch is currently scheduled to take place on August 30 at 7:26 a.m. ET. • This mission is designed to explore the universe, providing critical data on dark energy and exoplanets.

• NASA and SpaceX are targeting a liftoff for the Nancy Grace Roman Space Telescope at 7:26 a.m. EDT this Sunday. • The telescope will launch from Launch Complex 39A at the Kennedy Space Center in Florida aboard a SpaceX Falcon Heavy rocket. • This flagship mission aims to conduct vast, deep surveys to study dark matter, dark energy, exoplanets, and distant galaxies.