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• Researchers tested ARN-75039, an orally bioavailable small-molecule inhibitor, as a potential therapeutic against Lassa virus, which causes Lassa fever—a disease for which no preventative vaccine currently exists. • The compound represents a new approach to treating Lassa virus infection through direct viral entry inhibition rather than vaccines. • This research advances therapeutic options for a high-consequence pathogen that poses public health concerns, particularly in West African endemic regions.

Warmer weather has benefited some species in Britain, but others that rely on specific plants or habitats have struggled“Insectageddon” has not occurred, but there has been a loss of butterfly diversity over the past half a century, according to the world’s largest insect monitoring scheme.More than 44m butterfly sightings scientifically collected in Britain since 1976 show that of the 58 native species recorded, 33 species have declined and 25 have increased in number. Continue reading...

• CDC data reveals sexually transmitted disease rates fell among US adults last year, but congenital syphilis in newborns kept increasing. • This trend highlights persistent challenges in prenatal screening and treatment access for at-risk pregnant women. • Rising newborn syphilis threatens infant health outcomes, prompting calls for enhanced public health interventions.

Relacorilant, typically used to treat Cushing’s syndrome, could improve outcomes in platinum-resistant casesA drug originally used to treat a rare disease could extend the lives of patients with an aggressive form of ovarian cancer, according to a clinical trial.Platinum-resistant ovarian cancer occurs when the disease progresses within six months of starting platinum-based chemotherapy. This form of chemotherapy is different from other types because it uses compounds that contain platinum to destroy cancer cells by preventing them from dividing. Continue reading...

Figures gathered from children’s services and health trusts show 31 deaths were suicides, including six in under-18sMore than 50 young asylum seekers in the UK have died in the past decade, the majority by suicide, according to data compiled for the first time.Of 54 deaths of children and young people who claimed asylum between 2015 and 2024 in the care system, 31 were due to suicide, with seven homicides and eight fatal accidents. Only six deaths were due to health issues with two causes of death unknown, and 44 of the 54 have occurred since 2020. Continue reading...

• Eisai and Biogen announced positive top-line results from CLARITY AD trial extension on April 7, 2026, with lecanemab reducing cognitive decline by 27% over 18 months in 1,795 US patients. • Drug cleared 59% more amyloid plaques vs. placebo, with ARIA side effects in 12.6% of participants; full data at June AD/PD conference. • Approval could expand to mild cases, addressing 6.7 million US Alzheimer's sufferers; analysts predict $2.4 billion annual sales.

Reuters uncovers that the TSA shared more than 31,000 traveler records with ICE for immigration enforcementSign up for the Breaking News US email to get newsletter alerts in your inboxUS Immigration and Customs Enforcement (ICE) arrested more than 800 people following tips shared by federal airport security officials from the start of Donald Trump’s second presidency through February 2026, according to internal agency data reviewed by Reuters – a figure far above what was previously publicly known.The leads came from the Transportation Security Administration (TSA), which supplied ICE with records on more than 31,000 travelers for possible immigration enforcement, the data showed. Continue reading...

• The Institute for Supply Management’s Purchasing Managers Index revealed business input prices rose 7.7 percentage points in March 2026. • This spike reflects heightened costs amid geopolitical tensions and oil price volatility, contributing to broader inflationary pressures. • The data underscores challenges for corporate earnings and economic indicators as firms face elevated expenses.

• American Medical Association research reveals that over 80% of physicians are integrating AI tools into their clinical practices, reflecting widespread adoption across the medical profession. • Doctors express both optimism about AI's potential benefits and concerns about implementation, emphasizing the importance of physician involvement in AI development and deployment. • The survey highlights the transformative role of artificial intelligence in modern medicine while underscoring the need for continued physician oversight and ethical governance.

Fifty ‘founder’ bilbies were released in fenced breeding area in 2019 with the aim of establishing first wild population there in a centuryGet our breaking news email, free app or daily news podcastEfforts to reintroduce bilbies in the far south-west of New South Wales are showing signs of success, with numbers climbing to almost 2,000, seven years after the first breeding trial at Mallee Cliffs national park.Fifty “founder” bilbies, including 30 from Thistle Island off the coast of South Australia, were released in a fenced breeding area in 2019 with the aim of establishing a wild population in the Mallee Cliffs habitat for the first time in a century.Sign up for a weekly email featuring our best reads Continue reading...

Charities suggest ‘gendered understanding’ of crime means services often fail to recognise girls and young women as victimsAn increasing number of girls are being identified as victims of county lines exploitation, figures have shown.Data from Catch22, the charity that provides the national county lines support service, said girls and young women formed 22% of its caseload in 2025, up from 15% the previous year. Continue reading...

Exclusive: research finds Jackdaw field would provide only about 2% of current demand, and Rosebank only 1%Opening major new fields in the North Sea would make almost no difference to the UK’s reliance on gas imports, research has shown.The Jackdaw field, one of the largest unexploited gasfields in the North Sea, would displace only 2% of the UK’s current imports of gas, which would leave the UK still almost entirely dependent on supplies from Norway and a few other sources. Continue reading...

Citizen science data reveals early flowering, nesting and insect activity as global heating accelerate seasonal changeBluebells are flowering, swallows are returning and orange-tip butterflies are flying in what could become Britain’s earliest recorded spring.Records for early spring occurrences are being smashed as 2026 looks to be the earliest this century for frogspawn laying, blackbirds nesting, brimstone butterflies emerging and hazel flowering, according to Nature’s Calendar, which has logged citizen science records of seasonal change since 2000. Continue reading...

Russian advances slowing, thinktank’s data shows; 14 killed in Ukraine in massive drone and missile salvo. What we know on day 1,501Russia’s army recorded almost no territorial gains on the frontline in Ukraine in March for the first time in two-and-a-half years, according to analysis of data from the Institute for the Study of War (ISW) conducted by Agence France-Presse. The Russian army has been slowing in its advances since late 2025 – because of Kyiv’s localised breakthroughs in the south-east of the country. Across the entire frontline, the Russian army seized only 23 sq km (8.9 sq miles) in March, losing territory in some areas, according to the analysis. This figure excludes infiltration operations conducted by Russian forces beyond the frontline, as well as advances claimed by the Russian side but neither confirmed nor denied by the ISW.The Russian army made 319 sq km of gains in January and 123 sq km in February, which was then the smallest advance since April 2024. Its advance in March was the smallest since September 2023. The ISW attributed the slowdown to Ukrainian counteroffensives, but also to “Russia’s ban on using Starlink terminals in Ukraine” and “the Kremlin’s efforts to restrict access to Telegram”. The messaging app – very popular among Russians, including those fighting on the front – has been barely usable in recent months due to blocks imposed by the authorities. As in February, Russia lost ground on the southern section of the frontline, between the Donetsk and Dnipropetrovsk regions.Russian strikes killed 14 people in Ukraine on Friday, officials said, as Moscow launched the latest in an increasing number of daytime barrages. Moscow has been firing aerial broadsides at Ukraine throughout its more than four-year invasion, mostly at night, but in recent weeks has stepped up daytime attacks. The Russian military used more than 500 drones and dozens of missiles in its salvo on Friday, according to the Ukrainian air force.Russia’s Baltic oil export hubs at Ust-Luga and Primorsk remain unable to handle shipments after a series of Ukrainian drone attacks, prompting the country’s refineries to find alternative routes for export, industry sources said on Friday. The attacks have damaged port infrastructure and continued through the last two weeks of March, with at least five strikes on Ust-Luga in the space of 10 days. Sources said the export restrictions, along with disruptions at large refineries, could lead to a decrease in oil production in Russia. Traders said refineries had been unable to deliver diesel fuel to Primorsk for export since 22 March, leaving refineries in European Russia and Siberia without their most viable export route. Traders said refineries were having to consider more expensive rail transport routes to other export terminals.Zelenskyy has called on lawmakers to pass key legislation next week to avert a funding crisis, help Ukraine fight the war against Russia, and enact key reforms required for EU accession. Due to lagging reforms and slow legislative progress in late 2025 and early this year, Ukraine missed deadlines to unlock billions from its key lenders, economists said. With the need for external financing standing at $52bn this year – equivalent to about a quarter of annual economic output – the budget situation is desperate. “I have a list of key draft laws that are critical for securing funding,” the Ukrainian president said in remarks released on Friday. They range from strengthening the court system to reforming energy sector procedures. “I believe that members of parliament from all parties must understand the importance of these bills for Ukraine’s budget,” said Zelenskyy, who has a majority in parliament but its relations with his government have soured. Continue reading...

• The U.S. Bureau of Labor Statistics reported 145,000 nonfarm payroll additions in March, modestly below the 165,000 forecast but within a range suggesting labor market deceleration without crisis-level deterioration. • The unemployment rate remained flat at 3.9%, while average hourly earnings grew 3.8% year-over-year, slightly below the 4.0% pace in February and indicating moderating wage pressures that support the Fed's inflation narrative. • Economists cited seasonal adjustments and service sector softness as factors in the slower jobs growth, though private payroll strength and continued hiring in healthcare and professional services suggest underlying economic resilience despite recent market volatility.

• Moody's AI-based recession probability model has surged to 49%, just below the 50% threshold that historically signals economic recession within a year, amid mounting economic concerns. • The US labor market delivered a major disappointment with March data showing a loss of 92,000 jobs, far below expectations, while GDP growth projections have been revised downward from 1.4% to as low as 0.7%. • Recession forecasts from major institutions have escalated: Goldman Sachs raised odds to 30%, EY-Parthenon estimates risk at around 40%, and BlackRock CEO Larry Fink warned rising oil prices could trigger global recession.

Figures shows 42% of callers to Refuge identify former partner as abuser, but only 12% of adults recognise this possibilityThe risk posed to women by ex-partners in cases of abuse is underestimated by large swathes of the British public, according to the charity Refuge.Data from the charity’s helpline found that 42% of people who call Refuge for help identify a former partner as their abuser, a statistic which underlines how common it is for an ex to be a cause of harm after a relationship has ended. Continue reading...

About 38% of children in London live in relative poverty, compared with 29% in England as a wholeLondon has England’s highest levels of child poverty and most extreme concentrations of hardship, data has revealed. In two boroughs more than half of children live below the breadline.In Britain, child poverty rates flatlined in 2024-25 compared with the previous year. About 4 million youngsters (27%) live in households earning less than 60% of the national median income after housing costs are taken into account. Continue reading...

Cuts to family planning aid are linked to an 11% increase in deaths during pregnancy and childbirth in some countriesWhen Republican presidents win power in the US there is a stark consequence for many pregnant woman around the world – a significant rise in maternal mortality as aid is withdrawn, a new study has found.Global family planning aid typically drops under Republican presidents and then rises again by 48% once Democratic presidents are elected, the research, published in BMJ Global Health, finds. Continue reading...

In highly unusual move, Metropolitan police have released full transcript of call made by then chief of staff to PM UK politics live – latest updatesMorgan McSweeney did not disclose he was the prime minister’s chief of staff when he reported his phone stolen, according to a transcript released by the Metropolitan police.The Met has admitted the wrong address was recorded for the theft meaning that it was thought to be a street in Tower Hamlets, rather than a Westminster street of the same name. Continue reading...

Triple J will air without presenters while ABC News Breakfast is not expected to air as staff walk off the job to protest pay and conditionsFollow our Australia news live blog for latest updatesSign up for Guardian Australia’s free weekly media newsletter hereThe ABC’s flagship news programs including 7.30 and AM will be replaced by the BBC World Service when ABC journalists walk off the job for 24 hours for the first time in 20 years on Wednesday.Staff are protesting what they say is a low pay offer from ABC managing director Hugh Marks, as well as work conditions and the broadcaster’s refusal to rule out replacing journalists with AI bots. Continue reading...

National leader Christopher Luxon drops in preferred PM stakes with rise in people saying country heading in wrong directionThe personal ratings of New Zealand’s prime minister, Christopher Luxon, have dipped, polling shows, as his government’s handling of the economy fails to impress voters ahead of the November election.The RNZ-Reid Research poll, released on Monday, also found a growing number of people felt that New Zealand was heading in the wrong direction. Continue reading...

• A Phase 2 clinical trial led by Memorial Sloan Kettering Cancer Center demonstrated that engineered CAR-T cells targeting mesothelin showed a 52% overall response rate in 89 patients with advanced pancreatic and ovarian cancers. • The trial, results published March 19 in Cancer Cell, showed durable responses lasting over one year in 68% of responding patients, compared to historical response rates below 20% with conventional chemotherapy. • CAR-T therapy has revolutionized blood cancer treatment but remained ineffective against solid tumors until recent engineering advances, potentially opening a new therapeutic avenue for 400,000 Americans diagnosed with pancreatic and ovarian cancers annually.

Exclusive: War has led to 5m tonnes of greenhouse gas emissions in two weeks and is draining the global carbon budget faster than 84 countries combinedThe US-Israel war on Iran is a disaster for the climate, according to an analysis that finds it is draining the global carbon budget faster than 84 countries combined.As warplanes, drones and missiles kill thousands of people, level infrastructure and turn the Middle East into a gigantic environmental sacrifice zone, the first analysis of the climate cost has found the conflict led to 5m tonnes of greenhouse gas emissions in its first 14 days. Continue reading...

• Heartland Forward-commissioned research released March 19 reveals broad U.S. consensus on maternal health priorities and actionable steps forward. • Conducted in Bentonville, Ark., the poll finds Americans ready to address maternal care gaps nationwide. • Results point to unified public support for policy and community interventions to boost outcomes.

• Stagwell's Harris Poll found 88% of Republicans and 92% of Democrats view rigorous science as essential for progress, with 80-90% crediting US scientists for quality-of-life improvements. • Only 19% believe US leads China in research, 33% say falling behind; 90%+ across parties want US global leadership role. • If government funding lags, Americans favor businesses (23%) and nonprofits (19%) to fill gaps.

Steady UK opposition to the war and the US president’s insults mean MPs are finding it easier to point out the obviousWhen is a U-turn definitely a U-turn? To the consternation of politicians through the ages, this is rarely something within their control, but decided instead by the herd. And thus it is with Kemi Badnoch over Iran and Donald Trump.The Conservative leader would very much like it to be known that she had not changed her stance on the US-Israeli attacks on Iran, or on the US president. Continue reading...

Government’s first published land use framework maps how land is used and how it can be adapted to meet changing needsAbout 7% of England’s land – an area roughly two-and-a-half times the size of Cornwall – will need to be given over to nature, forests and renewable energy, to meet the UK’s environmental targets, new data shows.But there will still be enough land to grow the food needed, and to house a growing population, according to the government’s first “land use framework”, published on Wednesday.Placing a high priority on restoring peatland, all but 13% of which is degraded across England, but this will not include an outright ban on development such as wind or solar farms.Encouraging the “multi use” of land, for instance with livestock grazing alongside wind and solar farms, and wildlife protection and nature restoration on arable land.Encouraging local authorities to put nature reserves in urban areas as well as in the countryside.Grouse moors to come under closer scrutiny and tighter regulation, which will go further than EU rules.No new “right to roam” is included in the framework, but there will be a consultation on “making landowner liability more proportionate”, which could open up areas for public access.A national soil map will be published.A new “land use unit” will be established.Government planning for changes to the UK’s landscape under global heating of 2C above preindustrial levels, and of much higher heating of 4C. Continue reading...