Stem Cells

• An NIH-funded mouse study shows chronic colitis induces long-lasting epigenetic changes in gut stem cells, boosting AP-1 transcription factor activity and tumor growth potential. • Researchers analyzed over 52,000 cells, finding damage memories persist more than 100 days after inflammation ends, heritable across new cells. • The findings from Broad Institute scientists explain how sustained inflammation elevates colorectal cancer risk through dynamic epigenome alterations.

Frailty can typically only be lessened through lifestyle changes, but a stem cell therapy seems to target the underlying causes of the condition, boosting the mobility of frail older people