Treatment

• Soligenix's HyBryte for cutaneous T-cell lymphoma (CTCL) has a second Phase 3 trial underway with enrollment of approximately 80 subjects, interim analysis in Q2 2026, and top-line results in H2 2026. • Previous Phase 3 trials showed statistical significance in primary endpoints across multiple cycles, following FDA NDA submission and RTF letter. • The program targets unmet needs in rare dermatological cancers with ongoing FDA discussions for development path.

• Major U.S. health insurers are limiting coverage of GLP-1 drugs like Ozempic and Wegovy to their original FDA-approved use for diabetes management, excluding weight loss treatments. • According to industry analyst Andy, this shift reverses prior expansions amid rising costs and supply shortages, affecting millions of patients seeking obesity care. • The policy change aims to control spending on these high-demand medications, which have seen off-label use surge, potentially pushing patients toward alternatives or out-of-pocket payments.

• New York City logged 743 tuberculosis cases in 2025, down 11% from 2024, though numbers stay high compared to prior years, per Health Department data released March 24, 2026. • The department offers a new 1-month short-course regimen for latent TB, reducing visits from 3-9 months; 337 patients started it in 2025, with 75% completing by mid-February 2026. • On World TB Day March 27, NYC co-hosts a conference with updates; Commissioner Dr. Alister Martin notes TB killed more globally last year than COVID-19 or HIV.

• The FDA granted accelerated approval to a novel immunotherapy combination for metastatic pancreatic cancer on March 21, 2026, based on Phase 2 trial data showing a 35% response rate. • The drug combination demonstrated a median overall survival of 14.2 months compared to 11.8 months with standard chemotherapy in the clinical trial of 280 patients. • Pancreatic cancer remains one of the deadliest cancers with a five-year survival rate below 12%, making this approval potentially significant for the estimated 64,000 Americans diagnosed annually.

Judge rules that Trump’s health secretary did not go through proper procedures when issuing declarationRobert F Kennedy Jr, the health secretary, overstepped his power when he declared that gender-affirming treatments are unsafe, a federal judge has ruled.In a blow to the Trump administration’s attempts to limit access to gender transition procedures, Judge Mustafa Kasubhai ruled Thursday that Kennedy did not go through the proper procedures when issuing his 12-page declaration last December. Continue reading...

Exclusive: Drug users face felonies and prison under Prop 36, with analysis showing racial disparities and little helpCalifornia prosecutors have filed nearly 20,000 drug possession felony cases under a tough-on-crime measure passed in 2024. But despite promises to get people into services, the vast majority of those arrested have not received drug treatment, state data reveals.Proposition 36, a state ballot measure, enacted harsher penalties for minor theft and drug offenses, with proponents pledging the crackdown would lead to “mass treatment to keep people alive, out of jail, and off our streets”. Continue reading...

International researchers find ‘very little evidence’ medical form of the drug can treat anxiety, anorexia and other disordersCannabis is not an effective treatment for common mental health conditions despite the global surge in patients using it for that purpose, a review has found.Researchers concluded there was “very little evidence for its efficacy” in treating anxiety, anorexia nervosa, psychotic disorders, post-traumatic stress disorder or opioid use disorder. Continue reading...