Unprecedented

• The U.S. Department of Health and Human Services (HHS) has launched a coordinated, department-wide initiative to restore American leadership in clinical research. • The ONC is working to integrate clinical trial notifications into electronic health records to connect eligible patients with research opportunities during routine care. • ARPA-H is implementing modernization programs, including THRIVE and CATALYST, which utilize AI and machine learning to optimize dosing and predict safety before patient enrollment.

Police and hunters in Utsunomiya, 100km north of the capital, resume their search for animal that is not usually seen so close to TokyoA city in Japan has closed all its 94 primary and secondary schools after a bear was spotted in the municipality for the first time.Officials in Utsunomiya, a city of half a million people about 100km (62 miles) north of Tokyo, took action after a medium-sized black bear – estimated to be about one-metre-long – was seen near a park in the city on Saturday. The bear was spotted again on CCTV running just in front of two startled young men in the city centre, in the early hours of Sunday. Continue reading...

• The upcoming World Cup will feature an expanded format with 48 teams and 104 matches hosted across the United States, Mexico, and Canada. • The event faces unprecedented security challenges due to its scale and the current climate of global tensions and rising political violence. • To manage risks, the tournament has been granted a high-level federal security designation, similar to the Super Bowl, to ensure seamless coordination between federal, state, and local agencies.

• FIFA President Gianni Infantino has announced a new set of stadium policies and pre-match protocols ahead of the 2026 World Cup. • Key regulatory changes include the expansion of VAR powers and new penalties for players who cover their mouths during confrontations with officials. • The updates aim to manage the commercial explosion and global demand surrounding the tournament's expanded format.

Monday predicted to be hottest May day on record by large margin, as UK braces for ‘super El Niño’ summerTemperatures are expected to hit 35C in parts of England on Monday, in an “unprecedented” May heatwave.The Met Office is already predicting that records will be broken. A spokesperson said: “Today will be the hottest day in May in the UK in our temperature records, with highs of 35C expected. The current May record is 32.8C. Records are usually only broken by tenths of a degree, making this heatwave unprecedented for the time of year.” Continue reading...

Since November, state has seen 47 cases of people accidentally ingesting poisonous wild mushroomsHealth authorities in California’s Napa county reported that three people had been hospitalized after consuming poisonous wild mushrooms as the state continues to grapple with an “​​unprecedented outbreak” of toxic mushroom illnesses.Since November 2025, California has seen 47 cases of people accidentally foraging and eating poisonous wild mushrooms, including death caps, which can resemble edible species, and western destroying angel mus​​hrooms. Four people have died and several have required liver transplants. Continue reading...

Decades-long campaign powered by patient perspectives results in switch from PCOS – a name that caused confusion and undue suffering – to PMOSAfter more than a decade of global consultation, polycystic ovary syndrome (PCOS) – a condition that affects one in eight women – has been renamed.The hormonal disorder, estimated to impact 170 million women worldwide, will now be known as polyendocrine metabolic ovarian syndrome (PMOS). Continue reading...

All signs point to a record-low performance for Labour in May in what will be a moment of high jeopardy for Keir StarmerLabour is on track for its worst local election performance, data analysed by the Guardian shows, in a blow that will pile further pressure on Keir Starmer’s leadership.Barring a drastic change in fortunes, Labour’s vote-share could fall to historic lows across elections for councils in England and devolved parliaments in Wales and Scotland on 7 May, with big gains for Reform, the Greens and nationalist parties, according to recent polling. Continue reading...

As treasurer Jim Chalmers weighs ‘extreme uncertainty’, one economic scenario sees global growth plunging to just 2% in 2026Get our breaking news email, free app or daily news podcastThe International Monetary Fund has warned the US-Israel war on Iran risks creating an “energy crisis of an unprecedented scale” that could tip the global economy towards recession.The grim warning contained in the IMF’s latest World Economic Outlook comes as Jim Chalmers prepares to attend the organisation’s spring meetings in Washington DC this week, where he said he would be “joining with other countries continuing to call for an enduring end to the war”. Continue reading...

• President Trump escalated rhetoric against Iran, threatening 'unprecedented force' if Tehran fails to comply with ceasefire terms as the fragile two-week truce entered its second day on April 9, 2026. • Vice President JD Vance will lead a U.S. delegation to Islamabad, Pakistan on Saturday for direct talks with Iranian officials, joined by special envoy Steve Whit and Jared Kushner, aiming to convert the temporary ceasefire into a lasting agreement. • Early cracks are emerging in the ceasefire over disputed terms, Iran's nuclear program, and control of the Strait of Hormuz, with Iranian officials signaling the deal could be at risk.

The continental US registered its most abnormally hot month in 132 years of records, according to Noaa data March’s persistent unseasonable heat was so intense that the continental United States registered its most abnormally hot month in 132 years of records, according to federal weather data. And the next year or so looks to turn the dial up on global warmth even more, as some forecasts predict a brewing El Niño will reach super strength.Not only was it the hottest March on record for the US but the amount it was above normal beat any other month in history for the lower 48 states. March’s average temperature of 50.85F(10.47C) was 9.35F (5.19C) above the 20th-century normal for March. Continue reading...

• The Varieties of Democracy Institute at Sweden's Gothenburg University found that Trump's second term is characterized by swift concentration of executive power, suppression of dissent, and targeting of civil rights at a rate comparable to some coups d'état. • The Trump administration is flouting Congress and the judiciary, attacking courts while the Department of Homeland Security openly violates dozens of judicial orders, and has unilaterally reallocated federal funding including a $10 billion gift to the "Board of Peace" without congressional approval. • Republican-controlled Congress has "abdicated its constitutional role" by ceding legislative, fiscal, and oversight powers to the executive branch during 2025, while the administration undoes civil rights achievements and suppresses left-wing dissent.

• Team USA's sled hockey squad won gold at the 2026 Paralympics by capturing the final event of the competition, clinching an unprecedented fifth straight Paralympic title. • The American sled hockey team received their historic gold medals and heard the Star Spangled Banner play following the victory on March 15, 2026. • The achievement represents a dominant run of Paralympic success for the United States in winter sports competition.