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Southwest staff organized water cannon salute when aircraft arrived and Jon Jackson was met with cheers and applauseA Spirit Airlines pilot was given an emotional send-off into retirement by another airline after what was supposed to be his final flight was canceled amid Spirit’s sudden collapse on Saturday.Jon Jackson had been scheduled to fly his final flight into Baltimore-Washington international airport on Saturday when the low-cost airline ceased operations after running out of cash and rescue talks with the Trump administration failed. Continue reading...

US president’s latest outburst comes a day after he suggested a possible reduction in US troops in GermanyWhy does the US have military bases in Germany – and will Trump follow through on his threat to cut numbers?Donald Trump has again lashed out at Germany’s chancellor Friedrich Merz, saying he should focus on “fixing his broken country” and trying to end the Russia-Ukraine war – and spend less time “interfering” in Iran.“The Chancellor of Germany should spend more time on ending the war with Russia/Ukraine (Where he has been totally ineffective!),” Trump wrote in a social media post. Continue reading...

High fuel prices and passenger delays caused by EU’s EES entry-exit system causing problems, says trade bodyBusiness live – latest updatesEurope’s smaller airports may not survive if jet fuel shortages triggered by the Middle East crisis lead to widespread route cancellations, the industry’s trade body has warned.Although airlines insist that there are currently no supply issues within the normal four- to six-week horizon, the US-Israel war on Iran and the effective closure of the strait of Hormuz have doubled the price of jet fuel, prompting some carriers to cancel flights. Continue reading...

Strict protocols violated by corrections staff who wrongly believed sexual assault cases were ‘closed’, ombudsman findsFollow our Australia news live blog for latest updatesGet our breaking news email, free app or daily news podcastMen charged with alleged prison rapes were allowed to stay in shared cells – against strict protocols – by Queensland corrections staff who mistakenly believed their cases were “closed” and that they posed no risk, a report by the state’s ombudsman has found.The ombudsman’s inspection report of the Brisbane correctional centre raises a number of concerns about the facility, including extensive overcrowding, health facilities that are not fit for purpose and complaints that chicken served to detainees and staff is often undercooked. Continue reading...

Nearly 40% of cancellations could be avoided, researchers sayAbout one in 10 operations in England are cancelled with less than 24 hours’ notice or postponed, according to research..A study of elective surgery at 91 English NHS trusts found that 10% of operations were cancelled the day before the planned surgery date; while 9% were postponed when patients had their pre-op appointment. Continue reading...

• The FDA granted accelerated approval to a CRISPR-based gene therapy for severe sickle cell disease on April 20, marking the first approved genetic treatment editing patient blood cells to produce functional hemoglobin. • Clinical trials demonstrated 95% of treated patients experienced elimination or near-elimination of vaso-occlusive crises within 12 months, with durable responses observed for over two years post-treatment. • The therapy addresses a disease affecting approximately 100,000 Americans, primarily of African descent, offering potential cure for patients previously reliant on pain management and blood transfusions.

Lai Ching-te abandons visit after Seychelles, Mauritius and Madagascar revoke overflight permission Taiwan’s president, Lai Ching-te, has cancelled his trip to Eswatini, the democratic island’s only diplomatic ally in Africa, after his government said several countries had revoked overflight permits because of “intense pressure” from China.Lai was to leave on Wednesday for the 40th anniversary of King Mswati III’s accession. Continue reading...

• SpaceX's Starlink division announced commercial availability of direct-to-cell satellite service to US carriers including T-Mobile, Verizon, and AT&T beginning May 1, 2026, expanding beyond its existing emergency SOS functionality. • The service enables SMS and data connectivity in rural and remote areas where terrestrial networks are unavailable, with initial pricing set at $5 per month for basic coverage and $15 monthly for premium data tiers. • Industry observers note this development challenges traditional carrier infrastructure investments and could accelerate satellite communications adoption, though regulatory approval from the FCC is still pending final confirmation.

FC Basel and Polish stadium stop US rapper’s upcoming shows, after similar cancellations in France and UK over antisemitic commentsKanye West’s upcoming concerts in Poland and Switzerland have been cancelled, as a growing number of European countries have stopped or postponed the US rapper’s performances amid a furore over his past antisemitic comments.Swiss football club FC Basel, which is responsible for concerts and events that take place at its St Jakob-Park ground, told Reuters on Saturday that after reviewing a request for West to perform there in June, it decided against it. Continue reading...

Halt to seven weeks of fighting will be followed by first Israeli-Lebanese summit in decades. Plus, why are there so many false claims that some of cinema’s most famous scenes were improvised?Good morning.Donald Trump has announced a 10-day ceasefire in Lebanon, to be followed by a meeting between Israeli and Lebanese leaders next week, a deal that it is hoped will bring progress toward a parallel peace agreement between the US and Iran.What has Lebanon said? The Lebanese army warned people displaced from southern Lebanon about returning home because of intermittent shelling that was reported after the ceasefire came into effect.This is a developing story. Follow the liveblog here.What has Amazon said? It has called the claims in the lawsuit “entirely false and misguided”. The company said in a statement: “Amazon is consistently identified as America’s lowest-priced online retailer, and it is ironic that the attorney general seeks to have us feature higher prices in ways that would harm consumers and competition.” Continue reading...

Physicians issue reminder to public after TV doctor and CMS chief relays president’s claim on Don Jr podcastDonald Trump defended his consumption of diet soda by suggesting it might help prevent cancer, according to recent comments shared by Mehmet Oz in an interview with Donald Trump Jr.The remarks have even prompted some doctors to remind the public that, no, diet soda will not do anything to prevent cancer. Continue reading...

• Elijah Dottery, diagnosed with sickle cell anemia as a baby, became the first U-M patient to receive the newly FDA-approved stem cell therapy. • The treatment uses patient's own stem cells edited via CRISPR to produce functional hemoglobin, administered at Michigan Medicine. • This breakthrough matters for over 100,000 U.S. sickle cell patients, offering potential cure where prior therapies only managed symptoms.

Ron Prosor says verbal attack on Friedrich Merz referencing Nazi regime ‘erodes the memory of the Holocaust’Israel’s envoy to Germany has criticised a far-right Israeli cabinet member who made historically charged accusations against the German chancellor, Friedrich Merz, saying the attack “[eroded] the memory of the Holocaust”.In a rare rebuke of a top Israeli official by an active ambassador, Ron Prosor said he wished to “unequivocally condemn” Bezalel Smotrich’s tirade against Merz, in which he made reference to the Nazi regime and said: “You will not force us into ghettos again.” Continue reading...

NSW government urged to investigate if transport department refused to share cost of sensors that would detect a person entering coupling areaFollow our Australia news live blog for latest updatesGet our breaking news email, free app or daily news podcastThe potentially life-saving safety upgrades to Sydney’s light rail, which a former Transdev employee has alleged were cancelled in order to save money, would have only cost about $2.2m, according to the whistleblower.The New South Wales government has been urged to investigate whether its transport department declined to share the cost of installing sensors that would detect a person entering the coupling area between two joined trams after a fatal incident in 2023. Continue reading...

Treatment reset wayward immune system of patient with life-threatening conditions, say scientists, in a world firstA woman who lived with three life-threatening autoimmune diseases for more than a decade has returned to a near-normal life after a cell therapy reset her wayward immune system.The 47-year-old had had nine different treatments, none of which had a lasting impact, before receiving the therapy last year at University Hospital Erlangen in Germany. At the time, she required daily blood transfusions and permanent blood thinning medication to control her illness. Continue reading...

• NIH awarded $500 million in grants on April 7, 2026, to 15 US institutions for CRISPR-based gene therapies addressing 100,000 Americans with sickle cell disease. • Phase 2 trials at Boston Children's show 94% pain crisis reduction; total funding supports 200 patients over five years. • Initiative responds to 17% US mortality drop goal by 2030; 'Breakthrough for underserved communities,' per NIH Director.

• A Philadelphia cancer patient who had exhausted conventional treatment options was kept alive using a novel T-cell therapy developed and administered at Rutgers Health. • The case represents a breakthrough application of immunotherapy, offering hope to patients facing terminal cancer diagnoses with limited options. • The success demonstrates the therapeutic potential of advanced cellular therapies and highlights Rutgers Health's role in pioneering cutting-edge cancer treatment innovations.

• Soligenix's HyBryte for cutaneous T-cell lymphoma (CTCL) has a second Phase 3 trial underway with enrollment of approximately 80 subjects, interim analysis in Q2 2026, and top-line results in H2 2026. • Previous Phase 3 trials showed statistical significance in primary endpoints across multiple cycles, following FDA NDA submission and RTF letter. • The program targets unmet needs in rare dermatological cancers with ongoing FDA discussions for development path.

Rachel Reeves will address concerns about price rises and shortages with retailers as energy costs surgeThe bosses of the UK’s biggest supermarkets are to meet the chancellor on Wednesday as the government seeks to gauge the extent of potential price rises and shortages of household essentials amid a surge in energy, fuel and fertiliser costs.Rachel Reeves is meeting the bosses of Sainsbury’s, Tesco and Morrisons as concerns rise about the potential impact on the cost of living – including higher food prices – as a result of the Middle East conflict. Continue reading...

• Oregon Health & Science University researchers revealed a previously unknown system of directed fluid flows within cells that rapidly transport essential proteins to the cell's leading edge, published today in Nature Communications. • The breakthrough emerged from an accidental observation during a neurobiology course when scientists used lasers to track protein movement and discovered an unexpected wave of soluble actin being pushed forward rather than drifting randomly through the cell. • The discovery fundamentally reshapes understanding of cell migration, cancer metastasis, and wound healing by revealing that cells use active internal mechanisms rather than passive diffusion to position critical proteins.

• An NIH-funded mouse study shows chronic colitis induces long-lasting epigenetic changes in gut stem cells, boosting AP-1 transcription factor activity and tumor growth potential. • Researchers analyzed over 52,000 cells, finding damage memories persist more than 100 days after inflammation ends, heritable across new cells. • The findings from Broad Institute scientists explain how sustained inflammation elevates colorectal cancer risk through dynamic epigenome alterations.

• Researchers led by Professor Silvia von Karstedt discovered that loss of Caspase 8 protein in small cell lung cancer triggers inflammation promoting tumor growth and spread. • The study, published in Nature Communications on March 25, 2026, shows this loss reprograms cancer cells into an aggressive neuron-like state associated with relapse. • Findings from the CECAD Cluster of Excellence explain the cancer's notorious aggressiveness and poor prognosis.

New Nasa chief, Jared Isaacman, has outlined several changes to flagship moon programme ArtemisNasa is cancelling plans to deploy a space station in lunar orbit and will instead use its components to construct a $20bn base on the moon’s surface over the next seven years, its new chief, Jared Isaacman, said on Tuesday.Isaacman, who was sworn in at the agency in December, made the announcement at the opening of a day-long event at Nasa’s Washington headquarters at which he outlinedchanges he is making to the agency’s flagship moon programme Artemis. Continue reading...

Australian Education Union members to rally outside state parliament in dispute over pay and conditionsFollow our Australia news live blog for latest updatesGet our breaking news email, free app or daily news podcastClasses have been halted across Victoria as thousands of striking public school teachers, principals and education support staff prepare to descend on state parliament for a rally over pay and conditions.According to the Australian Education Union’s Victorian president, Justin Mullaly, up to 500 schools would either be closed or “significantly affected” as a result of the first strike in the state’s public school system in more than 13 years. Continue reading...

• A Phase 2 clinical trial led by Memorial Sloan Kettering Cancer Center demonstrated that engineered CAR-T cells targeting mesothelin showed a 52% overall response rate in 89 patients with advanced pancreatic and ovarian cancers. • The trial, results published March 19 in Cancer Cell, showed durable responses lasting over one year in 68% of responding patients, compared to historical response rates below 20% with conventional chemotherapy. • CAR-T therapy has revolutionized blood cancer treatment but remained ineffective against solid tumors until recent engineering advances, potentially opening a new therapeutic avenue for 400,000 Americans diagnosed with pancreatic and ovarian cancers annually.

Energy minister says war on Iran creating ‘uncertain environment’ but insists government doing ‘all the preparatory work’Follow our Australia news live blog for latest updatesGet our breaking news email, free app or daily news podcastSix oil ships bound for Australia have been cancelled in recent days but the federal government is not yet considering any drastic measures, the energy minister, Chris Bowen, says.Bowen said on Sunday that six ships from Malaysia, Singapore and South Korea, that had been expected to arrive next month, were cancelled or deferred. The federal government was working to replace the ships, with some already substituted, the minister told ABC TV. Continue reading...

About a quarter of prison places are unsafe, Ministry of Justice admitsThe government has reneged on a pledge to make all prison cells fire-safe or take them out of use by the end of next year, meaning tens of thousands of prisoners in England and Wales will remain at risk.The Ministry of Justice has admitted it has known for almost two decades that about a quarter of prison places are unsafe, putting the people housed in affected cells at risk. Continue reading...

Kiis FM radio host was suspended from work after an on-air argument with co-host Jackie ‘O’ HendersonKyle Sandilands has been sacked by ARN Media and his top-rating Kyle and Jackie O Show cancelled, but he says will fight to save his $100m contract.ARN Media said in a statement on Wednesday it had issued a notice of termination of contract to Sandilands and his company Quasar Media, over a dispute that began with an on-air argument between Sandilands and his co-host Jackie ‘O’ Henderson. Continue reading...