Targets

• A new clinical trial launched April 24, 2026 (NCT07549529), examines postural motor activation deficits following mild traumatic brain injury (mTBI) in US patients. • The study translates lab findings into physical therapy protocols for concussion rehabilitation, focusing on vestibular and balance impairments. • Affecting millions annually, mTBI recovery gaps could improve with targeted interventions, potentially reducing long-term disability rates by 30%.

• X-Energy, a nuclear power company, completed its Nasdaq debut with CEO Clay Sell announcing plans to deliver clean energy solutions to data centers and industrial customers. • The company is positioning itself as part of the broader reinvention of nuclear power to meet growing energy demands from artificial intelligence and cloud computing infrastructure. • The move reflects investor appetite for clean energy technologies as data center operators seek sustainable power sources to support AI expansion.

• The Trump administration pledges a crackdown on Chinese companies exploiting American-made AI models, focusing on national security risks. • Officials singled out China for foreign tech firms' unauthorized use of US AI technologies, vowing stricter enforcement measures. • The initiative aims to protect US intellectual property and prevent adversarial nations from leveraging American innovations in AI development.

• A $140 million super PAC war chest is poised to challenge Ohio Democrat Sherrod Brown's 2026 Senate return. • Funded by Republican donors, the group aims to exploit Brown's vulnerabilities in a key battleground. • This escalation underscores high stakes for Senate control amid Trump's midterm focus.

Exclusive: Australian Recreation Union says it plans to support candidates and parties that oppose gun control laws brought in after terror attackGet our breaking news email, free app or daily news podcastA gun users’ group targeting marginal Labor seats in next year’s New South Wales election plans to campaign for candidates who oppose the government’s firearm laws enacted after the Bondi terror attack.In an email sent to the electorate offices of 15 Labor backbenchers last week, the Australian Recreation Union (ARU) said it had recruited campaign managers across 17 “vulnerable” electorates, including Kogarah, the seat of the premier, Chris Minns, and Swansea, held by the police minister, Yasmin Catley. Continue reading...

• Anthropic released Claude API with native fine-tuning capabilities on April 19, allowing enterprises to customize the model on proprietary datasets without requiring base model retraining. • The fine-tuning service supports context windows up to 200,000 tokens and is priced at $8 per million input tokens and $24 per million output tokens, competitive with OpenAI's pricing structure. • This release directly challenges OpenAI's GPT-5 announcement and positions Anthropic as an alternative for organizations seeking customizable AI solutions with enhanced safety guardrails.

Met police look into incident near office of Iran International after attempted firebombing of a synagogueCounter terror investigators are examining three separate arson attacks in London against an Iranian dissident and Jewish targets amid fears the Iranian state may be behind them.The latest attack came on Wednesday evening at about 8.30pm against the offices of the parent group of a company that runs Iran International, a Persian news channel which opposes the regime in Tehran. Continue reading...

• McGovern Medical School at UTHealth Houston launched the Center for Innovation in Congenital Heart Disease, a multidisciplinary center bringing together experts in medicine, science, and engineering to transform understanding and treatment of the condition. • A major research focus involves recreating early human heart development using stem cells and bioprinted structures to study how congenital defects form. • The center bridges discovery and clinical care by advancing research, developing technologies, and translating innovations into patient treatment solutions across a lifetime of care.

Experts say our preoccupation with net overseas migration figures has distracted from a more meaningful discussion on the ‘scale of temporariness’Get our breaking news email, free app or daily news podcastAustralia should set immigration targets to achieve a “stable temporary population” to address the ballooning number of nonpermanent residents that has stretched the country’s public services and housing, a new report argues.Temporary migrants as a share of the total population has more than doubled over the past 15 years, from 2.7% in 2010, to more than 6%. Continue reading...

• Tesla shares rose 7.2% Thursday after the company announced successful deployment of advanced autonomous driving features in two additional states, bringing the full self-driving beta program to 15 states nationwide. • Multiple Wall Street analysts upgraded Tesla's stock, raising average price targets by 12-15%, citing accelerated path to profitability and potential for robotaxi revenue streams beginning in late 2026. • The autonomous driving announcement offset broader semiconductor sector weakness, with Tesla demonstrating differentiation from legacy automakers lacking comparable self-driving capabilities.

Trump claims Iranians welcome US strikes and lower court judges challenge Trump’s ‘war on rule of law’ – key US politics stories from Monday 6 April at a glanceDonald Trump was asked at a press conference Monday if his war on Iran was winding down or ramping up. His response: “I can’t tell you.”The US president’s comments came as diplomatic negotiations aimed at halting the war in the Middle East appeared to be faltering. Continue reading...

Exclusive: Health secretary’s pledges in doubt as analysis shows health service will not deliver key improvementsThe NHS is set to miss key targets to shorten waiting times for help at A&E, cancer care and planned hospital treatment, leaving millions of patients facing persistently long delays.The health service in England will not deliver a series of milestone improvements in its performance that ministers demanded it achieve by the time the fiscal year ends on Tuesday, a Guardian analysis of the NHS’s most recent data has found. Continue reading...

One struck a market in North Darfur and the other hit a truck carrying civilians in North Kordofan as the country’s civil war approaches its fourth yearAt least 28 civilians have been killed in two separate drone strikes in Sudan, according to health workers, as the country’s brutal civil war between the army and the paramilitary Rapid Support Forces approaches its fourth year.A strike hit a market in the town of Saraf Omra in North Darfur state on Wednesday, killing “22 people, including an infant, and injuring 17 more”, a health worker at the local clinic told AFP. Continue reading...

US president claims Iranian negotiators fear being killed by their own side; US military command claims to have damaged or destroyed over two-thirds of Iran’s missile, drone and naval production facilitiesIran rejects US ceasefire plan and submits its own amid push for talksAnalysis: Trump pitches Iran peace plan but military buildups rarely veer to off-rampChina’s foreign minister has said that a “glimmer of hope” for peace has emerged due to moves to stop the war in the Middle East, despite Tehran vowing to keep fighting.Wang Yi urged dialogue in separate calls with his Turkish and Egyptian counterparts, suggesting that both Tehran and Washington had shown signals they were willing to return to the negotiating table.Speaking of negotiations now is an admission of defeat.Prolonging this war would only result in further casualties and needless losses, leading to a further spillover of the conflict. Continue reading...

LSE research found some Reform councillors have denied the reality of climate science, and mention of climate has been removed from strategy documentsGood morning. Seven weeks from today, counting will be taking place for the English local elections and, unless the polls are more wrong than they have ever been before, Reform UK will be celebrating record wins. The commentary will focus on the implications for national politics. But councils have significant powers, and a report today says Reform wins in local government could have a significant impact on climate policy.We know that Reform UK are opposed to net zero, and they have pledged to cut green subsidies, but there is still some lack of clarity as to exactly what they would do on climate policy. Some Reform UK figures refuse point-blank to acknowledge that human-made global heating is a reality. Others claim they are just opposed to the pace of transition to renewables. But Nigel Farage, the party leader, has a long history of climate change scepticism.• Seven Reform UK-led councils have “scrapped” their climate targets and climate change denial has been expressed by Reform UK councillors in five councils. Some of these councils have removed content about climate change from strategy documents.• While work related to reducing greenhouse gas emissions continues in these councils, mitigating climate change is no longer explicitly cited as the motivation.In our study we found that ‘scrapping net zero’ is not only a policy position but a signal of a broader retreat from treating climate change as urgent. This takes the form of both delaying action and outright climate change denial. Voters should be aware that this is the case.In the upcoming local elections in May, should Reform UK expand its council base, we can expect further retreat from climate action. The government must be alert to this challenge, given the importance of local authorities to the delivery of national climate goals. Continue reading...

After series of delays, US space agency hopes to carry out first crewed flyby of the moon in more than half a century Nasa has begun returning its towering SLS rocket and Orion spacecraft to its Florida launch pad ahead of a planned flyby of the moon, after completing necessary repairs.Artemis engineers began the manoeuvre, which can take up to 12 hours, at 8pm local time. The US space agency will then begin the final preparations before its next launch window opens on 1 April. Continue reading...

• Iran hit Qatar's Ras Laffan Industrial City energy hub with missiles on March 18, 2026, causing extensive damage to QatarEnergy facilities. • Tehran also fired four ballistic missiles at Riyadh and attempted a drone attack on a Saudi gas facility, both intercepted by Saudi defenses. • The attacks mark a major escalation in the US-Israel-Iran war, driving oil prices higher and disrupting global supplies.

Government’s first published land use framework maps how land is used and how it can be adapted to meet changing needsAbout 7% of England’s land – an area roughly two-and-a-half times the size of Cornwall – will need to be given over to nature, forests and renewable energy, to meet the UK’s environmental targets, new data shows.But there will still be enough land to grow the food needed, and to house a growing population, according to the government’s first “land use framework”, published on Wednesday.Placing a high priority on restoring peatland, all but 13% of which is degraded across England, but this will not include an outright ban on development such as wind or solar farms.Encouraging the “multi use” of land, for instance with livestock grazing alongside wind and solar farms, and wildlife protection and nature restoration on arable land.Encouraging local authorities to put nature reserves in urban areas as well as in the countryside.Grouse moors to come under closer scrutiny and tighter regulation, which will go further than EU rules.No new “right to roam” is included in the framework, but there will be a consultation on “making landowner liability more proportionate”, which could open up areas for public access.A national soil map will be published.A new “land use unit” will be established.Government planning for changes to the UK’s landscape under global heating of 2C above preindustrial levels, and of much higher heating of 4C. Continue reading...

Leader uses first major economic speech to prioritise public services and reduction of inequality over growthA government led by the Green party would not set targets for GDP growth but would instead focus on people’s mental health, social cohesion and community welfare, Zack Polanski has said in a major speech to set out his plans for the economy.In his first policy address since taking over as leader of the Greens in England and Wales six months ago, Polanski condemned what he called “rip-off Britain”, where a minority of asset owners benefited at the expense of people obliged to pay unaffordable sums for housing and other basics. Continue reading...

Experts say attacks on Afghanistan are ‘defensive, not offensive’ but carry a risk of spiralling cycle of violenceAn escalating Pakistani campaign of airstrikes against targets in Afghanistan is aimed at forcing the Taliban authorities to abandon their support for Pakistani militants, according to officials and experts.The strategy is to impose such a steep cost on the Taliban administration that they act to prevent attacks emanating from Afghanistan. Yet it carries the risk of spiralling violence. Continue reading...

• The United States has struck 90 targets on Kharg Island, Iran's primary oil export terminal, marking an escalation in the conflict now in its third week of operations. • The strikes are intensifying global economic concerns, with energy markets rattled, supply chains disrupted, and fears of a potential food crisis as oil supplies face unprecedented pressure. • Iran has threatened to blockade the Strait of Hormuz and destroy tankers in response, prompting President Trump to request U.S. allies deploy warships to the region to maintain maritime access.

Afghan government reports zero casualties and accuses neighbouring country of wanting to ‘fuel the fire of war’Pakistan has targeted militant hideouts in Afghanistan’s Kandahar province overnight, as the fighting that erupted between the two neighbours late last month showed no signs of abating.The cross-border attacks, which have included Pakistani airstrikes in the Afghan capital, Kabul, is the deadliest yet between the countries. Islamabad has referred to the conflict as an “open war”, adding to concerns about regional stability as the US-Israeli conflict with Iran engulfs the Middle East and beyond. Continue reading...

The US military reports striking 15,000 targets in Iran since the war began, with President Trump stating forces 'totally obliterated' military sites on Kharg Island vital to Iran's oil network and threatening further action on oil infrastructure. This escalates as Iran reports 43,000 residential and commercial units damaged from US and Israeli strikes. Government spokesperson Fatemeh Mohajerani detailed the widespread destruction on Saturday. Global oil markets remain volatile with Hormuz disruptions.

Greenhouse gases dropped just 0.1% last year as environment minister criticises lack of improvementGreenhouse gas emissions in Germany have again missed targets set by the Climate Protection Act and barely fell at all in 2025.Emissions decreased by just 0.1% last year compared to the previous year, according to data from the German Environment Agency. Continue reading...

Ulta Beauty stock tumbled 12.5% on Friday, March 13, 2026, becoming the biggest decliner in the S&P 500 after reporting quarterly results that fell short of Wall Street profit expectations. The company's profit was hit by a 23% surge in selling, general, and administrative expenses, which reached $1 billion in the period. This decline highlights vulnerabilities in consumer discretionary sectors amid broader market pressures from oil price volatility, with analysts watching for potential impacts on retail spending. Upcoming earnings from peers may signal if this is an isolated miss or indicative of wider consumer weakness.

Iranian military said in a statement that oil and energy infrastructure belonging to firms that cooperated with the US would ‘immediately be destroyed’How have you been affected by the latest Middle East events?Saudi Arabia’s defence ministry is saying that two drones have been intercepted and destroyed in the eastern region.More now after reports of explosions in Dubai on Friday morning: thick black smoke rose over the financial hub’s skyline after what authorities described as a fire in an industrial area of the city-state. Continue reading...

President says forces ‘obliterated’ military targets on Kharg Island and warned its oil infrastructure could be nextMiddle East crisis – live updatesDonald Trump said Friday that US forces have “obliterated” military targets on Iran’s Kharg Island and warned that the oil infrastructure there could be next.“For reasons of decency, I have chosen NOT to wipe out the Oil Infrastructure on the Island,” Trump wrote on social media. “However, should Iran, or anyone else, do anything to interfere with the Free and Safe Passage of Ships through the Strait of Hormuz, I will immediately reconsider this decision.” Continue reading...