Articles about Cell

• Soligenix's HyBryte for cutaneous T-cell lymphoma (CTCL) has a second Phase 3 trial underway with enrollment of approximately 80 subjects, interim analysis in Q2 2026, and top-line results in H2 2026. • Previous Phase 3 trials showed statistical significance in primary endpoints across multiple cycles, following FDA NDA submission and RTF letter. • The program targets unmet needs in rare dermatological cancers with ongoing FDA discussions for development path.

Rachel Reeves will address concerns about price rises and shortages with retailers as energy costs surgeThe bosses of the UK’s biggest supermarkets are to meet the chancellor on Wednesday as the government seeks to gauge the extent of potential price rises and shortages of household essentials amid a surge in energy, fuel and fertiliser costs.Rachel Reeves is meeting the bosses of Sainsbury’s, Tesco and Morrisons as concerns rise about the potential impact on the cost of living – including higher food prices – as a result of the Middle East conflict. Continue reading...

• Oregon Health & Science University researchers revealed a previously unknown system of directed fluid flows within cells that rapidly transport essential proteins to the cell's leading edge, published today in Nature Communications. • The breakthrough emerged from an accidental observation during a neurobiology course when scientists used lasers to track protein movement and discovered an unexpected wave of soluble actin being pushed forward rather than drifting randomly through the cell. • The discovery fundamentally reshapes understanding of cell migration, cancer metastasis, and wound healing by revealing that cells use active internal mechanisms rather than passive diffusion to position critical proteins.

• An NIH-funded mouse study shows chronic colitis induces long-lasting epigenetic changes in gut stem cells, boosting AP-1 transcription factor activity and tumor growth potential. • Researchers analyzed over 52,000 cells, finding damage memories persist more than 100 days after inflammation ends, heritable across new cells. • The findings from Broad Institute scientists explain how sustained inflammation elevates colorectal cancer risk through dynamic epigenome alterations.

• Researchers led by Professor Silvia von Karstedt discovered that loss of Caspase 8 protein in small cell lung cancer triggers inflammation promoting tumor growth and spread. • The study, published in Nature Communications on March 25, 2026, shows this loss reprograms cancer cells into an aggressive neuron-like state associated with relapse. • Findings from the CECAD Cluster of Excellence explain the cancer's notorious aggressiveness and poor prognosis.

New Nasa chief, Jared Isaacman, has outlined several changes to flagship moon programme ArtemisNasa is cancelling plans to deploy a space station in lunar orbit and will instead use its components to construct a $20bn base on the moon’s surface over the next seven years, its new chief, Jared Isaacman, said on Tuesday.Isaacman, who was sworn in at the agency in December, made the announcement at the opening of a day-long event at Nasa’s Washington headquarters at which he outlinedchanges he is making to the agency’s flagship moon programme Artemis. Continue reading...

Australian Education Union members to rally outside state parliament in dispute over pay and conditionsFollow our Australia news live blog for latest updatesGet our breaking news email, free app or daily news podcastClasses have been halted across Victoria as thousands of striking public school teachers, principals and education support staff prepare to descend on state parliament for a rally over pay and conditions.According to the Australian Education Union’s Victorian president, Justin Mullaly, up to 500 schools would either be closed or “significantly affected” as a result of the first strike in the state’s public school system in more than 13 years. Continue reading...

• A Phase 2 clinical trial led by Memorial Sloan Kettering Cancer Center demonstrated that engineered CAR-T cells targeting mesothelin showed a 52% overall response rate in 89 patients with advanced pancreatic and ovarian cancers. • The trial, results published March 19 in Cancer Cell, showed durable responses lasting over one year in 68% of responding patients, compared to historical response rates below 20% with conventional chemotherapy. • CAR-T therapy has revolutionized blood cancer treatment but remained ineffective against solid tumors until recent engineering advances, potentially opening a new therapeutic avenue for 400,000 Americans diagnosed with pancreatic and ovarian cancers annually.

Energy minister says war on Iran creating ‘uncertain environment’ but insists government doing ‘all the preparatory work’Follow our Australia news live blog for latest updatesGet our breaking news email, free app or daily news podcastSix oil ships bound for Australia have been cancelled in recent days but the federal government is not yet considering any drastic measures, the energy minister, Chris Bowen, says.Bowen said on Sunday that six ships from Malaysia, Singapore and South Korea, that had been expected to arrive next month, were cancelled or deferred. The federal government was working to replace the ships, with some already substituted, the minister told ABC TV. Continue reading...

About a quarter of prison places are unsafe, Ministry of Justice admitsThe government has reneged on a pledge to make all prison cells fire-safe or take them out of use by the end of next year, meaning tens of thousands of prisoners in England and Wales will remain at risk.The Ministry of Justice has admitted it has known for almost two decades that about a quarter of prison places are unsafe, putting the people housed in affected cells at risk. Continue reading...

Kiis FM radio host was suspended from work after an on-air argument with co-host Jackie ‘O’ HendersonKyle Sandilands has been sacked by ARN Media and his top-rating Kyle and Jackie O Show cancelled, but he says will fight to save his $100m contract.ARN Media said in a statement on Wednesday it had issued a notice of termination of contract to Sandilands and his company Quasar Media, over a dispute that began with an on-air argument between Sandilands and his co-host Jackie ‘O’ Henderson. Continue reading...

Clare Dupree, 48, who had severe mental illness, died after using a vape to start blaze at prison in GloucestershireThere were “missed opportunities” that could have prevented the death of a woman with severe mental illness from “sustained inhalation of smoke” after a fire in her prison cell, an inquest has found.Clare Dupree, 48, from Cardiff, died after she used a vape to start a fire at HMP Eastwood Park in Gloucestershire just after Christmas 2022. Continue reading...

• Engineers at Washington University in St. Louis discovered that cells can sense far beyond the surfaces they touch through a process called "depth mechano-sensing," with clusters of normal epithelial cells detecting layers as far as 100 microns away by tugging on surrounding collagen fibers. • Individual cancer cells can probe about 10 microns ahead, while normal cell clusters working together can sense 10 times farther, helping cells decide where to migrate and providing new insights into cancer cell behavior. • The findings, published in PNAS, could reveal new targets to prevent cancer from spreading and advance understanding of how cancer cells move through the body.

Streaming platform Hulu decides ‘not to move forward’ with reboot of hit 90s series, according to actressBuffy The Vampire Slayer will not return, its star Sarah Michelle Gellar has announced, saying a reboot of the 90s supernatural fantasy series had been cancelled.Hulu, the Disney-owned streaming platform, has decided not to pick up the planned sequel, according to the actor. Continue reading...

Frailty can typically only be lessened through lifestyle changes, but a stem cell therapy seems to target the underlying causes of the condition, boosting the mobility of frail older people

Neuron-powered computer chips can now be easily programmed to play a first-person shooter game, bringing biological computers a step closer to useful applications

Cortical Labs is building two data centres that will house its neuron-filled chips. The technology is still in the very early stages of development

The congenital condition spina bifida is often treated surgically in the womb, but many children still go on to have mobility issues. The addition of a patch made up of stem cells from donated placentas could improve their long-term outcomes

A trumpet-shaped, single-celled organism seems able to predict one thing will follow another, hinting that such associative learning emerged long before multicellular nervous systems