Cell

• Oregon Health & Science University researchers revealed a previously unknown system of directed fluid flows within cells that rapidly transport essential proteins to the cell's leading edge, published today in Nature Communications. • The breakthrough emerged from an accidental observation during a neurobiology course when scientists used lasers to track protein movement and discovered an unexpected wave of soluble actin being pushed forward rather than drifting randomly through the cell. • The discovery fundamentally reshapes understanding of cell migration, cancer metastasis, and wound healing by revealing that cells use active internal mechanisms rather than passive diffusion to position critical proteins.

• An NIH-funded mouse study shows chronic colitis induces long-lasting epigenetic changes in gut stem cells, boosting AP-1 transcription factor activity and tumor growth potential. • Researchers analyzed over 52,000 cells, finding damage memories persist more than 100 days after inflammation ends, heritable across new cells. • The findings from Broad Institute scientists explain how sustained inflammation elevates colorectal cancer risk through dynamic epigenome alterations.

• Researchers led by Professor Silvia von Karstedt discovered that loss of Caspase 8 protein in small cell lung cancer triggers inflammation promoting tumor growth and spread. • The study, published in Nature Communications on March 25, 2026, shows this loss reprograms cancer cells into an aggressive neuron-like state associated with relapse. • Findings from the CECAD Cluster of Excellence explain the cancer's notorious aggressiveness and poor prognosis.

New Nasa chief, Jared Isaacman, has outlined several changes to flagship moon programme ArtemisNasa is cancelling plans to deploy a space station in lunar orbit and will instead use its components to construct a $20bn base on the moon’s surface over the next seven years, its new chief, Jared Isaacman, said on Tuesday.Isaacman, who was sworn in at the agency in December, made the announcement at the opening of a day-long event at Nasa’s Washington headquarters at which he outlinedchanges he is making to the agency’s flagship moon programme Artemis. Continue reading...

Australian Education Union members to rally outside state parliament in dispute over pay and conditionsFollow our Australia news live blog for latest updatesGet our breaking news email, free app or daily news podcastClasses have been halted across Victoria as thousands of striking public school teachers, principals and education support staff prepare to descend on state parliament for a rally over pay and conditions.According to the Australian Education Union’s Victorian president, Justin Mullaly, up to 500 schools would either be closed or “significantly affected” as a result of the first strike in the state’s public school system in more than 13 years. Continue reading...

• A Phase 2 clinical trial led by Memorial Sloan Kettering Cancer Center demonstrated that engineered CAR-T cells targeting mesothelin showed a 52% overall response rate in 89 patients with advanced pancreatic and ovarian cancers. • The trial, results published March 19 in Cancer Cell, showed durable responses lasting over one year in 68% of responding patients, compared to historical response rates below 20% with conventional chemotherapy. • CAR-T therapy has revolutionized blood cancer treatment but remained ineffective against solid tumors until recent engineering advances, potentially opening a new therapeutic avenue for 400,000 Americans diagnosed with pancreatic and ovarian cancers annually.

Energy minister says war on Iran creating ‘uncertain environment’ but insists government doing ‘all the preparatory work’Follow our Australia news live blog for latest updatesGet our breaking news email, free app or daily news podcastSix oil ships bound for Australia have been cancelled in recent days but the federal government is not yet considering any drastic measures, the energy minister, Chris Bowen, says.Bowen said on Sunday that six ships from Malaysia, Singapore and South Korea, that had been expected to arrive next month, were cancelled or deferred. The federal government was working to replace the ships, with some already substituted, the minister told ABC TV. Continue reading...