Inflammation

• An NIH-funded mouse study shows chronic colitis induces long-lasting epigenetic changes in gut stem cells, boosting AP-1 transcription factor activity and tumor growth potential. • Researchers analyzed over 52,000 cells, finding damage memories persist more than 100 days after inflammation ends, heritable across new cells. • The findings from Broad Institute scientists explain how sustained inflammation elevates colorectal cancer risk through dynamic epigenome alterations.

Persistent inflammation in the gut, lungs and skin might lead to Alzheimer's disease, but lifestyle choices - from getting vaccinated to eating well - can keep inflammation under control

The Alzheimer’s field is being turned on its head as mounting evidence points to the disease beginning outside the brain many years before symptoms start. This may mean we have to totally rethink how we approach preventing and treating the condition