Regulatory Sequences

Researchers from Cold Spring Harbor Laboratory (CSHL) and global collaborators identified over 2.3 million conserved non-coding sequences (CNSs) across 314 plant genomes from 284 species, using a new computational tool called Conservatory. These ancient 'DNA switches' originated before flowering plants diverged from non-flowering ancestors more than 400 million years ago, with some confirmed essential for developmental functions through genetic editing. The discovery provides a comprehensive atlas for plant biology, aiding crop breeders in addressing drought and food shortages by fine-tuning traits. CSHL's Zachary Lippman described it as 'a new window into the evolution of life across eons.'

Researchers from Cold Spring Harbor Laboratory (CSHL), Hebrew University, and Sainsbury Laboratory Cambridge University published a study in Science identifying over 2.3 million conserved non-coding sequences (CNSs) across 314 plant genomes from 284 species, some originating more than 400 million years ago before flowering plants diverged from non-flowering ancestors. The team developed a new computational tool called Conservatory to locate these ancient DNA 'switches' essential for plant development, with co-first author Anat Hendelman confirming their function through genetic editing. This comprehensive atlas includes dozens of crop species and wild ancestors, offering plant biologists and breeders tools to address drought and food shortages by fine-tuning traits. CSHL's Zachary Lippman described it as 'a new window into the evolution of life across eons.'