Bio

• माइकल जैक्सन की बायोपिक 'Michael' ने अमेरिका और कनाडा के सिनेमाघरों में 97 मिलियन डॉलर की जबरदस्त ओपनिंग के साथ शुरुआत की, जिसने 2015 में 'Straight Outta Compton' द्वारा बनाए गए 60.2 मिलियन डॉलर के पिछले म्यूजिक बायोपिक रिकॉर्ड को तोड़ दिया। • जैक्सन एस्टेट द्वारा सह-निर्मित और Lionsgate द्वारा वितरित इस फिल्म ने नकारात्मक समीक्षाओं और उत्पादन संबंधी समस्याओं को पार करते हुए अंतरराष्ट्रीय स्तर पर 120.4 मिलियन डॉलर के साथ मजबूत प्रदर्शन किया। • फिल्म की 217.4 मिलियन डॉलर की वैश्विक ओपनिंग म्यूजिक बायोपिक्स के लिए एक नया कीर्तिमान है, जो 2018 में 'Bohemian Rhapsody' द्वारा अर्जित 51 मिलियन डॉलर की डेब्यू कमाई से काफी अधिक है।

Michael Jackson biopic has shrugged off controversy, bad reviews and a troubled production to take $217m worldwide, including $97m in North AmericaMichael, the big-budget Michael Jackson biopic, has shrugged off bad reviews and a troubled production to launch with a $97m opening in North American theaters, contributing to its enormous $217m (£160m, A$303m) worldwide box office and shattering the record for the biggest biopic opening of all time.The film, a highly authorised portrayal of the “king of pop” that was co-produced by the Jackson estate and stars Jackson’s nephew Jaafar Jackson, took $120.4m internationally and $97m domestic – combining to surpass Oppenheimer’s $180.4m worldwide opening weekend in 2023 and Bohemian Rhapsody’s $124m in 2018. Continue reading...

Thousands of research papers have been published based on participants’ data, but there are questions over protection of private informationWith the revelation that the confidential health records of half a million British volunteers have been put up for sale on a Chinese website, we take a look at what the UK Biobank project has achieved – and why concerns have been raised. Continue reading...

• Stanford University neuroscientists discovered a blood-based biomarker (phosphorylated tau-217) that reliably predicts Alzheimer's disease development one to two decades before cognitive decline appears, according to research published April 20. • The biomarker was identified through analysis of blood samples from 2,500 cognitively healthy individuals followed for 15 years, with positive predictive value exceeding 92% in early-stage detection. • The finding could enable preventative therapies targeting amyloid and tau proteins before neurodegeneration becomes irreversible, potentially transforming Alzheimer's treatment approaches.

Study shows signature changes more pronounced in people with genetic risk, raising hopes for new therapiesChanges to microbes that live in the gut can identify people at greater risk of Parkinson’s disease long before symptoms develop, according to work that also raises hopes for new therapies.Researchers discovered signature changes in the gut microbiome that are more pronounced in people with a genetic risk for Parkinson’s and even more stark in those diagnosed with the disease. Continue reading...

The author, who will interview members of royal family for book, says being chosen for role is a ‘profound honour’Anna Keay, a historian whose most celebrated book is about Britain’s republican period, has been confirmed as Queen Elizabeth II’s official biographer.Keay will interview members of the royal family and the late queen’s friends and servants. She will also have access to the monarch’s personal and official papers held in the royal archives. Continue reading...

• The Broad Institute is leveraging artificial intelligence to accelerate drug discovery, designing new antibiotics and predicting drug toxicity with greater accuracy than traditional methods. • The AI systems are also being applied to identify specific genes, molecules, and cells that might serve as therapeutic targets for disease treatment. • This computational approach promises to dramatically speed up the drug development pipeline and reduce the cost and time required to bring new medications to patients.