Scientists Identify 2.3 Million Ancient DNA Regulatory Sequences Conserved in Plants for 400 Million Years

Researchers from Cold Spring Harbor Laboratory (CSHL), Hebrew University, and Sainsbury Laboratory Cambridge University published a study in Science identifying over 2.3 million conserved non-coding sequences (CNSs) across 314 plant genomes from 284 species, some originating more than 400 million years ago before flowering plants diverged from non-flowering ancestors. The team developed a new computational tool called Conservatory to locate these ancient DNA 'switches' essential for plant development, with co-first author Anat Hendelman confirming their function through genetic editing. This comprehensive atlas includes dozens of crop species and wild ancestors, offering plant biologists and breeders tools to address drought and food shortages by fine-tuning traits. CSHL's Zachary Lippman described it as 'a new window into the evolution of life across eons.'