Disease

• Stanford University neuroscientists discovered a blood-based biomarker (phosphorylated tau-217) that reliably predicts Alzheimer's disease development one to two decades before cognitive decline appears, according to research published April 20. • The biomarker was identified through analysis of blood samples from 2,500 cognitively healthy individuals followed for 15 years, with positive predictive value exceeding 92% in early-stage detection. • The finding could enable preventative therapies targeting amyloid and tau proteins before neurodegeneration becomes irreversible, potentially transforming Alzheimer's treatment approaches.

• The FDA granted accelerated approval to a CRISPR-based gene therapy for severe sickle cell disease on April 20, marking the first approved genetic treatment editing patient blood cells to produce functional hemoglobin. • Clinical trials demonstrated 95% of treated patients experienced elimination or near-elimination of vaso-occlusive crises within 12 months, with durable responses observed for over two years post-treatment. • The therapy addresses a disease affecting approximately 100,000 Americans, primarily of African descent, offering potential cure for patients previously reliant on pain management and blood transfusions.

• McGovern Medical School at UTHealth Houston launched the Center for Innovation in Congenital Heart Disease, a multidisciplinary center bringing together experts in medicine, science, and engineering to transform understanding and treatment of the condition. • A major research focus involves recreating early human heart development using stem cells and bioprinted structures to study how congenital defects form. • The center bridges discovery and clinical care by advancing research, developing technologies, and translating innovations into patient treatment solutions across a lifetime of care.

• Thomas Jefferson University launched a multicenter clinical trial led by Manisha Verma, MD, and Victor Navarro, MD, at Jefferson Einstein Philadelphia Hospital to improve palliative care for advanced liver disease patients. • Advanced liver disease causes significant scarring and loss of function, leading to serious health challenges with limited quality-of-life support. • Funded by the Patient-Centered Outcomes Research Institute and published in JAMA Internal Medicine, the trial addresses a major care gap for ALD patients nationwide.

• A new VCU Health study indicates alcohol-related liver disease prevalence may be twice as high as previously estimated because of underreported alcohol consumption. • The research uncovers hidden scale of liver damage, challenging prior data on this growing public health issue. • Findings highlight need for better screening and awareness amid rising alcohol use disorders in the US.

• FDA has approved an investigational new drug application for synthetic CAR-T (sCAR-T) therapy targeting autoimmune conditions. • The clearance enables clinical trials to test this engineered cell therapy in US patients with refractory autoimmune diseases. • sCAR-T represents a novel approach adapting cancer immunotherapy for immune disorders, potentially offering durable remissions.

Charity advises replacing seed and nut feeders, where birds gather, with small amounts of mealworms, fat balls or suetGarden birds should not be fed seeds and nuts over the summer months, the RSPB has said, in an attempt to reduce the spread of avian diseases.Bird lovers are being urged to take down their bird feeders between May and October to help birds such as the greenfinch, whose numbers have plummeted after the spread of trichomonosis, a parasitic disease transmitted more easily when birds cluster around feeders in the warmer months. Continue reading...

Treatment reset wayward immune system of patient with life-threatening conditions, say scientists, in a world firstA woman who lived with three life-threatening autoimmune diseases for more than a decade has returned to a near-normal life after a cell therapy reset her wayward immune system.The 47-year-old had had nine different treatments, none of which had a lasting impact, before receiving the therapy last year at University Hospital Erlangen in Germany. At the time, she required daily blood transfusions and permanent blood thinning medication to control her illness. Continue reading...

• NIH awarded $500 million in grants on April 7, 2026, to 15 US institutions for CRISPR-based gene therapies addressing 100,000 Americans with sickle cell disease. • Phase 2 trials at Boston Children's show 94% pain crisis reduction; total funding supports 200 patients over five years. • Initiative responds to 17% US mortality drop goal by 2030; 'Breakthrough for underserved communities,' per NIH Director.

• Oklahoma reports 1,218 heart-related deaths per 100,000 residents annually, substantially higher than the U.S. national rate of 920 deaths per 100,000, according to research from Compare the Market. • Heart and vascular diseases rank as Oklahoma's leading cause of death, followed by cancer, accidents and injuries, and respiratory diseases. • America's Health Rankings data shows 11.4% of Oklahoma adults have been told by health professionals they are at risk for cardiovascular disease, placing the state at 43rd out of 50 in cardiovascular risk awareness.

• The American Heart Association released a warning that 60% of US women are projected to develop cardiovascular disease by 2050, reflecting trends in aging populations and risk factor prevalence. • The projection underscores disparities in cardiovascular health outcomes between men and women and highlights the growing public health burden of heart disease. • This forecast emphasizes the need for enhanced prevention strategies, early intervention programs, and targeted health policy initiatives focused on women's cardiovascular health.

Federal agency, which normally supports state and local public health labs, has been hobbled by staff departuresSign up for the Breaking News US email to get newsletter alerts in your inboxThe US federal agency responsible for monitoring diseases has temporarily halted certain diagnostic testing, including those for rabies, human herpesvirus and several other infectious illnesses.The Centers for Disease Control and Prevention (CDC) released a list on Monday showing that more than two dozen types of testing are now unavailable. Continue reading...

• A new American College of Cardiology study of over 6,800 U.S. adults shows consuming more than nine daily servings of ultra-processed foods raises heart attack, stroke, or death risk by 67% compared to one serving. • Each additional serving increases risk by over 5% overall and more than 6% among Black Americans, with findings presented at the ACC Annual Scientific Session in New Orleans on March 28-30. • Dr. Michele Arthurs of Kaiser Permanente advises checking labels and strategies like pre-eating healthy meals or pairing chips with oranges to cut intake.

• The Military Health System's March 26, 2026 update covers research submissions and awards for the Department of War’s primary scientific gathering during March 23-27. • Features teamwork and tools for field medic training, plus new research on preventing dangerous diseases in U.S. Army and Navy contexts. • Army Reserve 'Connect to Protect' initiative emphasizes health protections amid weekly military medical news.

• Tulane University in New Orleans will host the inaugural US Chagas Disease Meeting on March 26-27, 2026, marking the first such conference on American soil. • The event convenes experts to discuss diagnosis, screening, research, and patient care for Chagas disease, now argued by some to be endemic in the US with approximately 300,000 infected Americans per CDC estimates. • Occurring at a pivotal moment, the meeting aims to boost awareness, improve public health responses, and advance peer-reviewed findings on this neglected parasitic disease.

The "world smells different" for people with Parkinson's disease, a discovery that could help doctors spot the condition sooner